Evidence map›Paper›PMID 41262729›Full record

SynthesisFrontiers in nutrition2025

Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.

Bin Wang, Yanle Xiong, Ning Lin, Jiaojiao Shi, Bo Zou, Xin Ma, Kaihong Zeng, Chao Kang

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bin Wang *Department of Clinical Nutrition, Longgang Centre Hospital of Shenzhen, Shenzhen, Guangdong, China.
Yanle Xiong *Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Ning Lin *Department of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Jiaojiao ShiDepartment of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Bo ZouDepartment of Clinical Nutrition, Longgang Centre Hospital of Shenzhen, Shenzhen, Guangdong, China.
Xin MaDepartment of Rehabilitation Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Kaihong ZengDepartment of Health Management Center & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chao KangDepartment of Clinical Nutrition, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A plateau hypoxic environment can increase the physiological burden on athletes. Although nutritional interventions have been recognized as a potential strategy to improve plateau acclimatization, evidence in support of specific dietary patterns is still lacking. This study compared the effects of different dietary interventions on cardiopulmonary fitness during plateau exercise through systematic evaluation and network meta-analysis methods. Methods: This study systematically reviewed relevant literature up to June 2025 and included 20 randomized controlled trials (RCTs) conducted at altitudes above 1,500 meters involving healthy participants aged 16 years and above who engaged in physical activities. The primary outcomes included cardiopulmonary indicators [maximal oxygen uptake (VO Results: A total of 20 randomized controlled trials involving 329 participants were included, evaluating eight dietary interventions. Moderate-quality evidence indicated that carbohydrate supplementation significantly improved the percentage of maximal oxygen uptake (VO Conclusions: Differences exist in the effects of different dietary interventions on cardiopulmonary fitness during altitude exercise. The current network meta-analysis indicates that carbohydrate-based strategies show beneficial effects, with carbohydrate plus glutamine supplementation demonstrating greater advantages in SpO Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251069629, identifier: CRD420251069629.

Indexed as

cardiopulmonary fitnesshigh-altitudenetwork meta-analysisnutritional interventionsrandomized controlled trial

Identifiers

PMID41262729
PMCPMC12624507

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.