Evidence map›Paper›PMID 41263002›Full record

ArticleCurrent health sciences journal

Statin Use in Cervical Artery Dissection and Subsequent Ischemic Stroke.

Omair Ul Haq Lodhi, Shadi Yaghi, Liqi Shu, Natali Chung, Christopher Robert Leon Guerrero, Josefin Emily Kaufman, Stefan Engelter, Christopher Traenka, Wayneho Kam, Adeel S Zubair and 3 more

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Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Omair Ul Haq LodhiDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Shadi YaghiDepartment of Neurology, Brown Medical School, Providence, RI, USA.
Liqi ShuDepartment of Neurology, Brown Medical School, Providence, RI, USA.
Natali ChungDepartment of Neurology, Brown Medical School, Providence, RI, USA.
Christopher Robert Leon GuerreroDepartment of Neurology, Atrium Health, Charlotte, NC, USA.
Josefin Emily KaufmanNeurology and Neurorehabilitation, University Department of Geriatric Medicine FELIX PLATTER-Department of Clinical Research, University of Basel, and University Hospital Basel, Basel, Switzerland.
Stefan EngelterNeurology and Neurorehabilitation, University Department of Geriatric Medicine FELIX PLATTER-Department of Clinical Research, University of Basel, and University Hospital Basel, Basel, Switzerland.
Christopher TraenkaNeurology and Neurorehabilitation, University Department of Geriatric Medicine FELIX PLATTER-Department of Clinical Research, University of Basel, and University Hospital Basel, Basel, Switzerland.
Wayneho KamDepartment of Neurology, University of North Carolina Health Rex, Raleigh, NC, USA.
Adeel S ZubairDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Mohammad AlmajaliDepartment of Neurology, University of Iowa, Iowa City, IA, USA.
João Pedro MartoDepartment of Neurology, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.
Muhammad AffanDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe role of statins in preventing recurrent ischemic strokes in the setting of non-traumatic cervical artery dissection remains unclear. This study, a secondary analysis of Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection (STOP-CAD) study, investigates the impact of statin therapy on subsequent ischemic stroke.

methodsSTOP-CAD, a multicenter retrospective observational study, included 4023 patients with non-major trauma-related CAD. For this sub study, we included 2610 patients with ischemic stroke, excluding those with non-ischemic presentations and missing statin information. Patients were stratified based on statin use at hospital discharge and a sensitivity analysis was conducted based on intensity: high-intensity, moderate-intensity, low-intensity, or no statin. Primary outcome was the incidence of subsequent ischemic stroke after hospital discharge. Secondary outcomes included major hemorrhage, mortality and 90-day functional outcomes. Statistical analyses included univariate analyses, Cox regression models to evaluate odds and hazard ratios.

resultsThere was no significant difference in subsequent ischemic strokes after hospital discharge between the statin group (3.1%) and no statin group (3.3%) (aHR 0.73 95% CI, 0.43-1.24, p=0.25). Similarly, the incidence of major hemorrhage, mortality and 90-day functional outcomes showed no significant differences between the groups.

conclusionStatin therapy did not significantly reduce the risk of subsequent ischemic stroke, major hemorrhage, functional outcome, or mortality. While statins are beneficial in reducing vascular events and improving outcomes in ischemic stroke, its benefits in CAD-related ischemic strokes are less clear. These findings highlight the need for individualized treatment strategies and further research to optimize secondary prevention in CAD-related stroke.

Indexed as

acute strokeCervical artery dissectionstatin

Identifiers

PMID41263002
PMCPMC12625784

What Socratic holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.