Evidence map›Paper›PMID 41263309›Full record

ArticleeLife2025

A stochastic RNA editing process targets a select number of sites in individual

Andrés B Crane, Michiko O Inouye, Suresh K Jetti, J Troy Littleton

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Andrés B CraneThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0002-0242-526X
Michiko O InouyeThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Suresh K JettiThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.
J Troy LittletonThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, United States.ORCID https://orcid.org/0000-0001-5576-2887

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Imaging Synaptic Transmission of Individual Active ZonesR01MH104536 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI J. TROY LITTLETON · 2014 to 2026
$4.7M
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone MaturationR01NS117588 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2021 to 2025
$1.9M
Effect of Nanoscale Active Zone Morphology on Synaptic Vesicle Release ProbabilityF31NS118948 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CRANE, ANDRES · 2020 to 2022
$103k
NIH HHS P40 OD018537NIMH NIH HHS MH104536NIMH NIH HHS R01 MH104536NINDS NIH HHS F31 NS118948NINDS NIH HHS F31NS118948NINDS NIH HHS NS117588NINDS NIH HHS R01 NS117588
6 · The paper itself

Abstract

RNA editing is a post-transcriptional source of protein diversity and occurs across the animal kingdom. Given the complete profile of mRNA targets and their editing rate in individual cells is unclear, single-cell RNA transcriptomes obtained by Patch-seq from

Indexed as

Drosophila melanogasterMotor NeuronsRNA EditingAnimalsDrosophilaDrosophila ProteinsLarvaRNA, MessengerDrosophila ProteinsRNA, MessengerADARD. melanogastermembrane excitabilityneuroscienceRNA editingsynaptic transmission

Identifiers

PMID41263309
PMCPMC12634045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.