Evidence map›Paper›PMID 41263536›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Upconverting Nanoparticle-Loaded Microneedles for Near-Infrared Responsive Delivery of Gonadotropins to Increase Success of In Vitro Fertilization.

Vivienne Tam, Rusvir Trana, Alfonso Nieto-Arguello, Ore-Oluwa Olasubulumi, Samuel Babity, Artiom Skripka, Fiorenzo Vetrone, Davide Brambilla, Marta Cerruti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vivienne TamMining and Materials Engineering, McGill University, 3610 Rue University, Montreal, Quebec, H3A 0C5, Canada.
Rusvir TranaBioengineering, McGill University, 3480 Rue University, Montreal, Quebec, H3A 0E9, Canada.
Alfonso Nieto-ArguelloFaculty of Pharmacy, Université de Montreal, 2940 chemin de Polytechnique, Montreal, Quebec, H3T 1J4, Canada.
Ore-Oluwa OlasubulumiBioengineering, McGill University, 3480 Rue University, Montreal, Quebec, H3A 0E9, Canada.
Samuel BabityFaculty of Pharmacy, Université de Montreal, 2940 chemin de Polytechnique, Montreal, Quebec, H3T 1J4, Canada.
Artiom SkripkaDepartment of Chemistry, Oregon State University, Corvallis, Oregon, 97331, USA.
Fiorenzo VetroneCentre Énergie, Matériaux et Télécommunications, Institut National de la Recherche Scientifique, Université du Québec, 1650 Boul. Lionel Boulet, Varennes, Québec, J3X 1P7, Canada.
Davide BrambillaFaculty of Pharmacy, Université de Montreal, 2940 chemin de Polytechnique, Montreal, Quebec, H3T 1J4, Canada.
Marta CerrutiMining and Materials Engineering, McGill University, 3610 Rue University, Montreal, Quebec, H3A 0C5, Canada.ORCID 0000-0001-8533-3071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro fertilization (IVF) requires repeated bolus injections of gonadotropins at precise times, making it a painful and stressful experience for women. Polymeric microneedles (MNs) present a painless alternative to hypodermic needles, but controlling the release of drugs through MNs remains a challenge. Here, we report the development of a hydrogel MN patch integrated with upconverting nanoparticles coated with light-breakable mesoporous silica (UCNP@LBMS) that releases the IVF gonadotropin, leuprolide, in response to near-infrared (NIR) light, while retaining the UCNPs within the MN patch. In rats, a 5 min NIR pulse of 2 W cm

Indexed as

Fertilization in VitroGonadotropinsLeuprolideMultifunctional NanoparticlesAnimalsFemaleHydrogelsLightNeedlesRatsRats, Sprague-DawleySilicon DioxideGonadotropinsHydrogelsLeuprolideSilicon Dioxideclinical translationdrug deliverylanthanideslight‐controlledpolymeric microneedlesupconverting nanoparticles

Identifiers

PMID41263536
PMCPMC12757993

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.