ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Three-dimensional choroidal vessels assessment in central serous chorioretinopathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo assess the choroidal vasculature with a novel three-dimensional (3D) algorithm in patients with central serous chorioretinopathy (CSCR).
methodsPatients with chronic CSCR were retrospectively included. Swept-source optical coherence tomography 12 × 12 mm scans were obtained. Automated choroidal segmentation was performed based on deep-learning ResUNet model. Phansalkar thresholding was adopted to binarize choroidal vasculature. Choroidal vessels were visualized in 3D maps segmented into 5 quadrants. Mean choroidal vessel diameter (MChVD), inter-vessel distance (IVD), choroidal thickness (ChT) and choroidal vascularity index (CVI) were calculated in CSCR and healthy eyes. Linear mixed models were used for analysis.
resultsThirty eyes of 25 CSCR patients and 30 eyes of 26 controls were included. Mean age of CSCR group was 51.2 ± 11.4 years, 24% were females. CSCR eyes showed significant increase in ChT and MChVD compared to controls in each sector (p < 0,001), with reduced IVD (p < 0.001). MChVD was increased in complex CSCR compared to simple CSCR in each sector, with significant differences in the nasal (p = 0.021), and temporal sectors (p = 0.020). CVI was reduced in complex CSCR compared to simple CSCR in each sector, with significant differences in the temporal (p = 0.017) and inferior sectors (p = 0.003). IVD in the central sector was reduced in active CSCR compared to inactive CSCR (p = 0.031).
conclusionsCSCR eyes demonstrated increased ChT and MChVD and decreased IVD compared to controls. Also, complex CSCR presented increased MChVD, along with reduced CVI compared to simple CSCR. Choroidal 3D vessel assessment represents an innovative non-invasive method to explore choroidal changes in CSCR.
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