Evidence map›Paper›PMID 41264005›Full record

ArticleArchives of microbiology2025

Caffeic acid from Desikacharya sp. TPB-4: A sustainable source with antimicrobial potential against Aeromonas caviae.

Vandana Sindhu, Sanjay Sharma, Arun Kumar Mishra, Satya Shila Singh

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Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vandana SindhuLaboratory of Cyanobacterial Systematics and Stress Biology, Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Sanjay SharmaLaboratory of Cyanobacterial Systematics and Stress Biology, Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Arun Kumar MishraLaboratory of Microbial Genetics, Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Satya Shila SinghLaboratory of Cyanobacterial Systematics and Stress Biology, Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh, India. satyashila@rediffmail.com.

Funding

Institute of Eminence, Banaras Hindu University, India IoE-6031
6 · The paper itself

Abstract

The escalating global threat of antimicrobial resistance necessitates the exploration of sustainable natural sources such as cyanobacteria for antioxidant and antimicrobial compounds. In this study, three hot-spring dwelling cyanobacterial strains- Mastigocladus ambikapurensis TA-9, Desikacharya sp. TPB-4 and Westiellopsis sp. TPR-29 were investigated for their bioactive potential. Among these, TPB-4 exhibited the highest total phenolic and flavonoid contents along with strong free-radical scavenging activity. The methanolic extract of TPB-4 demonstrated antimicrobial effects. TLC-purification followed by HR-LCMS analysis revealed caffeic acid as one of the major active constituents. The mechanistic investigations with caffeic acid showed multiple antimicrobial targets including disruption of bacterial (Aeromonas) outer membranes, cell wall integrity and central dogma as evidenced by FTIR and proteomic analyses. These findings highlight the potentiality of hot-spring isolates as natural repositories of bioactive polyphenols, role of proteomics in elucidating antimicrobial targets and suggested caffeic acid as a promising candidate for developing natural antimicrobial therapeutics.

Indexed as

Aeromonas caviaeAnti-Bacterial AgentsCaffeic AcidsAntioxidantsMicrobial Sensitivity TestsAnti-Bacterial AgentsAntioxidantscaffeic acidCaffeic AcidsAntimicrobialCaffeic acidFTIRHot springsProteomics

Identifiers

PMID41264005

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.