Evidence map›Paper›PMID 41264029›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Demographic, lifestyle, and clinical factors associated with muscle function in patients with head and neck cancer: a prospective cohort study.

Tycho Zuijlen, Brenda Berendsen, Femke Jansen, C René Leemans, Robert P Takes, José A Hardillo, Johannes A Langendijk, Irma M Verdonck-de Leeuw, Remco de Bree, Caroline M Speksnijder

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tycho ZuijlenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, P.O. Box 85.500, 3508 GA, Utrecht, The Netherlands.
Brenda BerendsenDepartment of Human Movement Science, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
Femke JansenDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Location Vrije Universiteit, Amsterdam, The Netherlands.
C René LeemansDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Location Vrije Universiteit, Amsterdam, The Netherlands.
Robert P TakesDepartment of Otolaryngology-Head and Neck Surgery, Radboudumc, Nijmegen, The Netherlands.
José A HardilloDepartment of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center Cancer Institute, Erasmus UMC, Rotterdam, The Netherlands.
Johannes A LangendijkDepartment of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands.
Irma M Verdonck-de LeeuwDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Location Vrije Universiteit, Amsterdam, The Netherlands.
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, P.O. Box 85.500, 3508 GA, Utrecht, The Netherlands.
Caroline M SpeksnijderDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht University, P.O. Box 85.500, 3508 GA, Utrecht, The Netherlands. C.M.Speksnijder@umcutrecht.nl.

Funding

Alpe Young Investigator 12820Dutch Cancer Society VU 2013-5930
6 · The paper itself

Abstract

purposeThis study examined changes in muscle function over two years following diagnosis in patients with head and neck cancer (HNC), and identified demographic, lifestyle, and clinical factors associated with muscle function.

methodsData were derived from the NETherlands QUality of life and Biomedical cohort (NET-QUBIC), including patients with newly diagnosed HNC. Muscle function was assessed using the 30-second chair stand test (30s-CST) at baseline (pre-treatment), and 6, 12, and 24 months post-treatment. Linear mixed models (LMM) were used to evaluate changes in 30s-CST scores over time and to explore the influence of factors such as age, sex, education, body mass index, smoking, alcohol use, WHO performance status, tumor site, tumor stage, comorbidities, and treatment modality. Both main and interaction effects were examined.

resultsOf the 737 included patients, 622 completed at least one 30s-CST. Univariable LMM showed a significant decline in 30s-CST scores between baseline and 6 months. However, the multivariable LMM analysis showed no significant changes over time or interactions between time and the examined factors. Muscle function was significantly lower in patients with severe comorbidities, current smokers, non-drinkers, those with low education, or a WHO score of one. Each additional year of age was associated with a decrease in muscle function.

conclusionAlthough muscle function declined initially, this was not significant after adjusting for demographic, lifestyle, and clinical factors. Comorbidity, smoking, alcohol use, education, WHO score, and age were significantly associated with muscle function. These findings highlight the need to consider these factors when designing and implementing rehabilitation programs.

Indexed as

Head and Neck NeoplasmsLife StyleAdultAgedAge FactorsAlcohol DrinkingCohort StudiesComorbidityFemaleHumansLinear ModelsMaleMiddle AgedNetherlandsProspective StudiesQuality of LifeHead and neck neoplasmsMalnutritionMuscle strengthPhysical fitnessSarcopenia

Identifiers

PMID41264029

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.