Evidence map›Paper›PMID 41264120›Full record

ArticleJournal of neuro-oncology2025

Tumor-associated M2 macrophages shape the cerebrospinal fluid immunoprofile, and the soluble CD163/type I interferon ratio correlates with prognosis in high grade glioma.

Shunsuke Yamanishi, Hiroaki Nagashima, Kazuhiro Tanaka, Yusuke Ikeuchi, Masahiro Nakahara, Hirofumi Iwahashi, Satoshi Nakamizo, Hirotomo Tanaka, Masamitsu Nishihara, Tomoo Itoh and 2 more

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shunsuke YamanishiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Hiroaki NagashimaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. hn0628hn@med.kobe-u.ac.jp.
Kazuhiro TanakaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yusuke IkeuchiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Masahiro NakaharaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Hirofumi IwahashiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Satoshi NakamizoDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Hirotomo TanakaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Masamitsu NishiharaDepartment of Neurosurgery, Nishi-Kobe Medical Center, Kobe, Japan.
Tomoo ItohDepartment of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan.
Yoshihiro MuragakiCenter for Advanced Medical Engineering Research and Development, Kobe University, Kobe, Japan.
Takashi SasayamaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVarious immune cells infiltrate glioma tissues and secrete inflammatory mediators. This study aimed to identify inflammatory mediators in the CSF that are indicative of the tumor microenvironment (TME) and have prognostic significance in patients with glioma.

methodsThis retrospective study included patients newly diagnosed with glioma. CSF concentrations of soluble CD163 (sCD163), a marker of M2 macrophages, were measured using a human ELISA kit and compared with the percentage of CD163-positive area in tumor tissue (tCD163 (%)). In addition, concentrations of 37 inflammatory mediators in CSF were quantified using Bio-Plex Pro™ Human Inflammation Assays. Correlations among these mediators and their associations with clinical outcomes were analyzed.

resultsA total of 125 patients were evaluated for sCD163. Both sCD163 levels and tCD163%) were significantly higher in WHO grade 4 gliomas and showed a positive correlation. Multivariate correlation analysis revealed a clear segregation of CSF inflammatory mediators into sCD163 positive-corelate and sCD163 negative-correlate clusters. sCD163 positive-correlate cluster includes various TNF superfamilies and sTNF receptors, while sCD163 negative-correlate cluster includes interferon-α/β (IFN-α/β) and verous interleukines (ILs). Among patients with IDH-wild glioblastoma, the ratio of sCD163/IFN-α/β was associated with poor prognosis.

conclusionElevated sCD163 levels in CSF were positively associated with various TNFSFs and sTNFRs and inversely associated with type 1 IFNs and various ILs, suggesting a dominant influence of tumor associated M2 macrophages on the TME. The sCD163/type I IFN ratio may serve as a potential prognostic indicator in patients with IDH-wildtype glioblastoma.

Indexed as

Antigens, CDAntigens, Differentiation, MyelomonocyticBrain NeoplasmsGliomaInterferon Type IMacrophagesReceptors, Cell SurfaceTumor-Associated MacrophagesAdultAgedBiomarkers, TumorCD163 AntigenFemaleFollow-Up StudiesHumansMaleAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkers, TumorCD163 AntigenInterferon Type IReceptors, Cell SurfaceCerebrospinal fluidGliomaInflammatory mediatorsCD163Tumor microenvironmentType I interferon

Identifiers

PMID41264120

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.