Evidence map›Paper›PMID 41264168›Full record

ArticleInternational ophthalmology2025

Increased risk of sympathetic ophthalmia in ocular surgical patients with trauma history.

Alan Y Hsu, Chun-Chi Chiang, Yi-Ching Shao, Hou-Ting Kuo, Ning-Yi Hsia, Chun-Ting Lai, Bing-Qi Wu, Hsin Tseng, Chun-Ju Lin, Peng-Tai Tien and 4 more

Abstract readMulticenter Study
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In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alan Y HsuDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Chun-Chi ChiangDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Yi-Ching ShaoDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Hou-Ting KuoDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Ning-Yi HsiaDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Chun-Ting LaiDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Bing-Qi WuDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Hsin TsengDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Chun-Ju LinDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan. doctoraga@gmail.com.
Peng-Tai TienDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
Huan-Sheng ChenAn-Shin Dialysis Center, Excelsior Renal Service Co., Ltd. Taiwan Branch, Taichung, Taiwan.
Yu-Hsun WangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Yi-Yu TsaiDepartment of Ophthalmology, China Medical University Hospital, China Medical University, No. 29, Yude Rd., North Dist., Taichung, 404327, Taiwan.
James Cheng-Chung WeiDepartment of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan. jccwei@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the risk of sympathetic ophthalmia (SO) among ocular surgery patients with and without a history of ocular trauma.

methodsThis cohort study used the multi-institutional TriNetX platform to enroll ocular surgery patients with and without a history of ocular trauma from January 1, 2005, to December 31, 2023. The primary outcome was the risk of developing SO in the ocular trauma group compared to those without.

resultsA total of 16,198 patients who underwent ocular surgery with prior ocular trauma (mean [SD] age, 45.59 [23.26] years; 28.58% female) and 16,198 without trauma history (46.49 [25.13] years; 28.74% female) were included. Patients with prior trauma had a higher risk of SO, with increased risk evident from 3 months after the index date (HR, 13.45; 95% CI, 1.77-102.20) and persisting through 18 years (7.21; 2.83-18.37). Stratified analyses showed elevated risk after anterior segment surgery (21.62; 2.91-160.40) and vitreoretinal surgery (5.84; 1.31-26.08). Increased risk was also observed for both closed globe injury (21.97; 2.96-163.00) and open globe injury (10.80; 2.54-45.92). Subgroup analysis showed higher SO risk among patients aged 18-39 years (5.70; 1.28-25.48) and 40-64 years (17.71; 2.36-132.60), in both males (12.96; 3.07-54.59) and females (9.10; 1.15-71.82), and among White patients (19.28; 2.58-144.00).

conclusionsOur findings suggest that patients who have undergone ocular surgery with histories of ocular trauma should be closely monitored for the development of SO.

Indexed as

Eye InjuriesOphthalmia, SympatheticOphthalmologic Surgical ProceduresAdolescentAdultFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsYoung AdultOcularSurgerySympathetic ophthalmiaTraumaUveitis

Identifiers

PMID41264168

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.