Evidence map›Paper›PMID 41264200›Full record

ArticleActa neurologica Belgica2026

Neurofilament light chain levels as a biomarker in idiopathic intracranial hypertension: correlations with papilledema and radiological findings.

Ahmed Hamdy, Shimaa Elgamal, Reem Algamal, Hadeer Elsaeed AboElfarh, Muhammad Abdelshafi Elsayed, Ahmed Reda Abdelmeguid Moustafa, Yasmeena Abdelall Kozaa, Hossam Egila, Osama Elshafei

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Article in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ahmed HamdyDepartment of Neurology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt. ahmedhamdy@mans.edu.eg.ORCID http://orcid.org/0000-0002-3646-9594
Shimaa ElgamalDepartment of Neurology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt.
Reem AlgamalDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hadeer Elsaeed AboElfarhDepartment of Neurology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.
Muhammad Abdelshafi ElsayedDepartment of Neurology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.
Ahmed Reda Abdelmeguid MoustafaMansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Yasmeena Abdelall KozaaMansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hossam EgilaDepartment of Neurology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.
Osama ElshafeiDepartment of Neurology, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic intracranial hypertension (IIH) is marked by elevated intracranial pressure with risk of vision loss. Neurofilament light chain (NfL), a marker of axonal injury, may reflect optic nerve damage in IIH.

objectiveTo assess the relationship between cerebrospinal fluid (CSF) and serum NfL levels, papilledema severity, and radiological findings in patients with IIH.

methodsA cross-sectional study was performed on 34 women with IIH and 34 age- and sex-matched healthy controls. Demographics, clinical features, ophthalmological evaluation, lumbar puncture opening pressure measurement, brain MRI/MRV, and ONSD ultrasound were performed. NfL levels were measured in CSF and serum using ELISA. Correlations with papilledema grade (Frisén scale) and radiological findings were analyzed.

resultsIIH patients had higher BMI (34.2 vs. 27.3 kg/m², p < 0.001) and ONSD (6.39 vs. 5.40 mm, p < 0.001). CSF NfL levels were elevated (median 79.8 ng/L) and positively correlated with papilledema grade (r = 0.383, p = 0.031) but negatively with ONSD (r = -0.352, p = 0.041). ONSD correlated strongly with papilledema (r = 0.456, p = 0.009) and lumbar puncture pressure (r = 0.502, p = 0.002). Serum NfL showed no significant difference between patients and controls (p = 0.562) and no correlation with disease severity.

conclusionCSF NfL correlates with papilledema grade and may serve as an objective biomarker of optic nerve damage in IIH. Its complementary role alongside ONSD suggests potential for a dual biomarker approach, combining acute pressure assessment with cumulative axonal injury monitoring.

Indexed as

Neurofilament ProteinsPapilledemaPseudotumor CerebriAdultBiomarkersCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMiddle AgedYoung AdultBiomarkersneurofilament protein LNeurofilament ProteinsBiomarkersIdiopathic intracranial hypertensionIntracranial pressureNeurofilament light chainOptic nerve sheath diameterPapilledema

Identifiers

PMID41264200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.