Evidence map›Paper›PMID 41264215›Full record

ArticleApplied biochemistry and biotechnology2026

Exosomal FOSL1 From Cancer-associated Fibroblasts Drives the Progression and Pro-tumorigenic M2 Macrophage Polarization of Hepatocellular Carcinoma By Activating PLAU Transcription.

Kai Bai, Ruopeng Liang, Jian Li, Kun Zhao

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kai BaiDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou, 45000, Henan, China. zzuganai@163.com.
Ruopeng LiangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou, 45000, Henan, China.
Jian LiDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou, 45000, Henan, China.
Kun ZhaoDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou, 45000, Henan, China. kzhao292@163.com.

Funding

the research of the mechanism of histone lysine methyltransferase G9a in promoting the occurrence of hepatocellular carcinoma and the targeted intervention of nanodrugs 242102310424
6 · The paper itself

Abstract

Exosomes derived from cancer-associated fibroblasts (CAFs) play a crucial role in cancer development. Fos-like antigen 1 (FOSL1) exhibits oncogenic properties across various malignancies. However, the specific role of FOSL1 in CAFs-derived exosomes (CAFs-EXO) in hepatocellular carcinoma (HCC) has not been previously explored. This study aimed to investigate whether CAFs-EXO transfer FOSL1 to HCC cells and to examine the functional consequences of this transfer. HCC-related CAFs and their exosomes were used to incubate HCC cells. Cell proliferation and migration/invasion were assessed. The percentage of CD11b

Indexed as

Cancer-Associated FibroblastsCarcinoma, HepatocellularExosomesLiver NeoplasmsMacrophagesProto-Oncogene Proteins c-fosCell Line, TumorCell MovementCell ProliferationHumansProto-Oncogene Proteins c-fosCancer-associated fibroblastsExosomesFOSL1Hepatocellular carcinomaTumor-associated macrophages

Identifiers

PMID41264215

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.