ArticleProceedings of the National Academy of Sciences of the United States of America2025
An AINTEGUMENTA phosphoswitch controls bilateral stem cell activity during secondary growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mulberry ERF Transcription Factor MnERF23 Is a Positive Regulator of Plant Drought Tolerance.Plants (Basel, Switzerland) · 2026Article
- A receptor kinase complex refines cambium activity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- ERECTA-family receptor kinases: versatile regulators of plant developmental signaling.The Plant journal : for cell and molecular biology · 2026Review
- Evolutionary adaptations to the hormonal regulation of vascular tissue development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An updated history of TDIF-PXY signalling: a study in cell fate and tissue patterning.The New phytologist · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Plant stem cells have the remarkable ability to give rise to distinct tissues and organs throughout development. Two concentric cylinders of actively dividing stem cells are the main drivers of radial thickening during secondary growth, each producing distinct vascular cell types toward the inside and the outside. While the molecular mechanisms underlying their initiation have been well studied, it remains unclear how these stem cell layers determine which cell type is generated. Here, we demonstrate that the cross-talk between the ERECTA (ER) receptor pathway and auxin signaling controls the amount and choice of output tissue in these two stem cell regions. Mechanistically, we show that the ER pathway phosphorylates the transcription factor AINTEGUMENTA (ANT), thereby modulating bilateral stem cell activity and favoring the differentiation of only one type of cell. Our results thus show that the phosphorylation status of ANT regulates root girth and biomass accumulation by influencing bilateral stem cell production. This highlights the critical role of posttranslational modifications in plant growth and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.