Evidence map›Paper›PMID 41264285›Full record

ArticleThe FEBS journal2026

Plant-produced encapsulin displays non-typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles.

Carly A Charron, Angelo Kaldis, Shabnam Shamriz, Justin B Renaud, Moussa S Diarra, Christopher P Garnham, Rima Menassa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carly A CharronBiology Department, Western University, London, ON, Canada.
Angelo KaldisLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, Canada.
Shabnam ShamrizBiology Department, Western University, London, ON, Canada.
Justin B RenaudLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, Canada.
Moussa S DiarraGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON, Canada.
Christopher P GarnhamLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, Canada.ORCID 0000-0002-1035-6970
Rima MenassaBiology Department, Western University, London, ON, Canada.ORCID 0000-0003-3536-0332

Funding

Agriculture and Agri-Food Canada
6 · The paper itself

Abstract

Foodborne illnesses have major public health and economic impacts. Non-typhoidal Salmonella enterica serovars (Salmonella), associated with the consumption of contaminated poultry products, are among the most common causes of foodborne illness in humans. Vaccination of poultry flocks is one of the main methods to prevent Salmonella infection in poultry; however, the vaccines currently available have limitations. Because of this, there is an urgent need for more effective Salmonella vaccines. Ferric enterobactin receptor (FepA) is a Salmonella outer-membrane protein that shows promise as a vaccine antigen due to its important role in iron acquisition and its ubiquity on the surface of Salmonella. Here, we describe the production of encapsulin nanoparticles displaying antigenic epitopes from FepA in Nicotiana benthamiana. Five FepA-encapsulin fusion proteins were transiently expressed in N. benthamiana leaves and targeted to either the chloroplast or the cytosol. We found that accumulation was highest in the chloroplast, with levels over 0.7 mg·g

Indexed as

Antigens, BacterialBacterial Outer Membrane ProteinsNanoparticlesSalmonella entericaSalmonella VaccinesAnimalsChloroplastsEpitopesNicotianaPlant LeavesPlants, Genetically ModifiedRecombinant Fusion ProteinsAntigens, BacterialBacterial Outer Membrane ProteinsEpitopesRecombinant Fusion ProteinsSalmonella Vaccinesencapsulinplant molecular farmingprotein nanoparticleSalmonellasubunit vaccine

Identifiers

PMID41264285
PMCPMC13044985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.