Evidence map›Paper›PMID 41264359›Full record

ArticleJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 532025

Proportion and Profile of Autistic Children Not Acquiring Spoken Language Despite Receiving Evidence-Based Early Interventions.

Giacomo Vivanti, Michael V Lombardo, Ashley Zitter, Brian Boyd, Cheryl Dissanayake, Sarah Dufek, Helen E Flanagan, Suzannah Iadarola, Ann Kaiser, So Hyun Kim and 9 more

Abstract read
In one paragraph

Article in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giacomo VivantiA.J. Drexel Autism Institute, Drexel University.
Michael V LombardoLaboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia.
Ashley ZitterDepartment of Psychological and Brain Sciences, Drexel University.
Brian BoydSchool of Education, University of North Carolina at Chapel Hill.
Cheryl DissanayakeOlga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University.
Sarah DufekDepartment of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis Health.
Helen E FlanaganProvincial Preschool Autism Service, IWK Health Centre.
Suzannah IadarolaDepartment of Pediatrics, Developmental & Behavioral Pediatrics, University of Rochester Medical Center.
Ann KaiserPeabody College of Education and Human Development, Vanderbilt University.
So Hyun KimCenter for Autism and the Developing Brain, Weill Cornell Medical College.
Lynne LevatoDepartment of Pediatrics, Developmental & Behavioral Pediatrics, University of Rochester Medical Center.
Catherine LordDavid Geffen School of Medicine, UCLA.
Joshua PlavnickCollege of Education, Michigan State University.
Diana L RobinsA.J. Drexel Autism Institute, Drexel University.
Sally J RogersDepartment of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis Health.
Isabel M SmithProvincial Preschool Autism Service, IWK Health Centre.
Tristram SmithDepartment of Pediatrics, Developmental & Behavioral Pediatrics, University of Rochester Medical Center.
Aubyn StahmerDepartment of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis Health.
Linda WatsonSchool of Education, University of North Carolina at Chapel Hill.

Funding

Prevalence and profile of treatment non-responders in Autism Early InterventionR01DC017181 · NIDCD · DREXEL UNIVERSITY · PI VIVANTI, GIACOMO · 2019 to 2021
$1.5M
NIDCD NIH HHS R01 DC017181
6 · The paper itself

Abstract

objectiveTo determine the proportion and profile of preschoolers on the autism spectrum who do not acquire spoken language despite receiving evidence-supported interventions that target spoken language.

methodsWe examined an aggregate dataset comprising 707 preschoolers on the autism spectrum who had received evidence-supported interventions to determine the proportion and profile of those who experienced limited progress in spoken language. Interventions were delivered through programs affiliated with university research settings and ranged in duration from 6 to 24 months. Spoken language outcomes were determined from parent-report measures, which were validated against direct assessments and natural language samples.

resultsApproximately two-thirds of children who were non-speaking at baseline were using single words or more complex spoken language by intervention exit. Those who remained non-speaking had lower baseline motor imitation scores, derived mainly from parent reports. Approximately half of the children who were minimally speaking (i.e. had single words or no words) at baseline were combining words by intervention exit. Those who did not acquire word combinations had lower baseline scores in cognitive, social, adaptive and motor imitation measures, and shorter intervention duration. Age at intervention start influenced spoken language advancement differently depending on the initial spoken language level. The odds of acquiring spoken language did not differ based on the intervention received.

conclusionsApproximately one-third of children who had limited or no spoken language at baseline did not advance to spoken language stages following intervention. Development of spoken language was associated with modifiable factors at the child and intervention level.

Identifiers

PMID41264359
PMCPMC12681502

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.