Evidence map›Paper›PMID 41264770›Full record

ReviewProtein & cell2026

GlycoRNA research: from unknown unknowns to known unknowns.

Li Yi, Yitong Zhou, Chi Zhang, Haojie Lu, Yixuan Xie

Abstract readReview
In one paragraph

Review in Protein & cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li YiNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0009-0002-2872-2569
Yitong ZhouNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0009-0004-2439-3985
Chi ZhangNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0001-7636-0377
Haojie LuNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0003-3477-7662
Yixuan XieNHC Key Laboratory of Glycoconjugates Research, Department of Biochemistry and Molecular Biology, Institutes of Biomedical Sciences and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.ORCID 0000-0002-8512-6053

Funding

Greater Bay Area Institute of Precision Medicine I0036(A)National Key R&D Program of China 2024YFA1306300National Natural Science Foundation of China 22434001National Natural Science Foundation of China 22507114
6 · The paper itself

Abstract

Recent discoveries have revealed the existence of glycosylated RNAs (glycoRNA), in which glycans are covalently linked to small non‑coding RNAs and are predominantly localized to the cell surface. Since the initial discovery in 2021, glycoRNA has become an emerging field: 4 years in glycoRNA research have produced advances in labeling, imaging, and mass spectrometry that now highlight the role of glycoRNA in cell communication, immune regulation, and disease progression. In this review, we summarize current knowledge of glycoRNA biogenesis, detection techniques, and biological functions, and discuss how these findings reshape the future interface between glycobiology and RNA biology.

Indexed as

PolysaccharidesRNA, Small NucleolarAnimalsGlycosylationHumansPolysaccharidesRNA, Small NucleolarglycoRNAmass spectrometryRNA modification

Identifiers

PMID41264770
PMCPMC12959772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.