ArticleHepatology communications2025
Neighborhood disparities and metabolic dysfunction-associated steatotic liver disease in children with overweight or obesity.
Article in Hepatology communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Sex-specific associations between pubertal development and MASLD in children: evidence from the PROC study.Pediatric research · 2026Article
- Social Vulnerability and Age at Sleeve Gastrectomy among Adolescents: Does ZIP Code Make a Difference? - A COSMIC Retrospective Study.Obesity surgery · 2026Article
- Psychosocial aspects and mental health burden of pediatric MASLD.Frontiers in endocrinology · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease, yet known biological risk factors do not fully explain its development. This study evaluated the association between social determinants of health (SDH)-including income, education, housing, and environmental factors-and MASLD in children with overweight or obesity.
methodsThis cross-sectional study included children with overweight or obesity evaluated in pediatric gastroenterology clinics, stratified by the presence of MASLD. Participants' residential census tracts were linked to the California Healthy Places Index (HPI), where higher scores indicate greater socioeconomic advantage. Generalized linear regression models, adjusted for age, sex, race, ethnicity, and body mass index (BMI), assessed associations between SDH and MASLD.
resultsThe study included 888 children (mean age: 12.8±2.9 y, mean BMI: 30.6±6.4 kg/m2). Children with MASLD lived in neighborhoods with significantly lower HPI scores than those without MASLD (-0.22 vs. -0.03; 41st vs. 49th percentile, p=0.01). They also resided in areas with significantly lower socioeconomic advantage across multiple HPI subdomains, including housing (-0.16 vs. 0.03; 44th vs. 51st percentile, p<0.001) and economic (-0.38 vs. -0.12; 36th vs. 55th percentile, p<0.001) scores.
conclusionsChildren with MASLD were more likely to live in neighborhoods with greater socioeconomic and environmental disadvantage than their peers with overweight or obesity but without MASLD. These findings highlight potential SDH targets for public health interventions aimed at reducing MASLD risk in children.
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