Evidence map›Paper›PMID 41265171›Full record

ArticleInternational dental journal2026

Genetic Variants in DVL3 are Associated With Root Maldevelopment, Tooth Agenesis, Mesiodens, and Oral Exostoses.

Piranit Kantaputra, Narumon Bunpiem, Yeliz Guven, Kanich Tripuwabhrut, Tugba Kalayci, Ebru Imren, Nuttaporn Sengtae, Chawalid Pianmee, Apitchaya Pruksametanan, Sissades Tongsima and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Piranit KantaputraDivision of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand; Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. Electronic address: dentaland17@gmail.com.
Narumon BunpiemDental Section, Rayong Hospital, Rayong, Thailand.
Yeliz GuvenDepartment of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkiye.
Kanich TripuwabhrutDivision of Orthodontics, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
Tugba KalayciDepartment of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkiye.
Ebru ImrenDepartment of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkiye.
Nuttaporn SengtaeCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
Chawalid PianmeeDental Center, Surin Hospital, Muang Surin, Surin, Thailand.
Apitchaya PruksametananDepartment of Pediatric Dentistry, Faculty of Dentistry, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Sissades TongsimaMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Chumpol NgamphiwMedical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Katsushige KawasakiDivision of Oral Anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Atsushi OhazamaDivision of Oral Anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
James R Ketudat CairnsSchool of Chemistry, Institute of Science, and Center for Biomolecular Structure, Function and Application, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DVL3 regulates tooth initiation, root formation, and craniofacial patterning through canonical and non-canonical WNT signalling. The objective of this study was to investigate the dental and craniofacial phenotypes associated with rare or novel DVL3 variants in Thai and Turkish patients. It aimed to broaden the understanding of the clinical spectrum of DVL3-related conditions, particularly their role in odontogenesis and craniofacial development. We evaluated 11 patients from Thai and Turkish cohorts with confirmed DVL3 variants through clinical, radiographic, and whole-exome and Sanger sequencing. All patients exhibited variable dental anomalies, including root malformations, oral exostoses, and mesiodens. Unlike the broader craniofacial and skeletal manifestations seen in syndromic Robinow syndrome, these cohorts demonstrated a dental-predominant phenotype, indicating a possible genotype-phenotype distinction. These findings highlight the role of canonical-noncanonical WNT signalling dysregulation in odontogenesis and dentoalveolar development. Rare or novel DVL3 variants can manifest primarily as complex dental anomalies with or without syndromic features. Early recognition and genetic evaluation of such cases are essential for accurate diagnosis, clinical management, and counselling. This study provides novel insights into the role of DVL3 in tooth and craniofacial development, with implications for future research and interdisciplinary care.

Indexed as

AnodontiaDishevelled ProteinsTooth AbnormalitiesTooth RootAdolescentAdultChildChild, PreschoolFemaleGenetic VariationHumansMaleOdontogenesisPhenotypeTurkeyDishevelled ProteinsDVL3 protein, humanRoot anomaliesRoot malformationsupernumerary toothTaurodontismTorus mandibularisTorus palatinus

Identifiers

PMID41265171
PMCPMC12671360

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.