Evidence map›Paper›PMID 41266309›Full record

ArticleNature communications2025

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice.

Eloïse Marques, Stephen P Burr, Alva M Casey, Richard J Stopforth, Chak Shun Yu, Keira Turner, Dane M Wolf, Marisa Dilucca, Vincent Paupe, Suvagata Roy Chowdhury and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Eloïse MarquesMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-9658-3199
Stephen P BurrMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-8865-126X
Alva M CaseyMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-7242-3251
Richard J StopforthCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0054-7503
Chak Shun YuMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0009-0004-3106-9681
Keira TurnerMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0001-9586-9523
Dane M WolfMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Marisa DiluccaDepartment of Medicine, Addenbrooke's hospital, Cambridge Biomedical Campus, Cambridge, UK.
Vincent PaupeMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Suvagata Roy ChowdhuryMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Victoria J TyrrellDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Robbin KramerMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0009-0008-6575-8847
Yamini M KanseMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Chinmayi PednekarCancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Chris A PowellMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
James B StewartBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-2902-4968
Julien PrudentMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0003-3821-6088
Michael P MurphyMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Michal MinczukMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Valerie B O'DonnellDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-4089-8460
Clare E BryantDepartment of Medicine, Addenbrooke's hospital, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-2924-0038
Patrick F ChinneryMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-7065-6617
Arthur KaserCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1419-3344
Alexander von KriegsheimCancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4952-8573
Dylan G RyanMRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. RYAND67@tcd.ie.ORCID http://orcid.org/0000-0003-4553-9192

Funding

Wellcome Trust
6 · The paper itself

Abstract

Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochondrial tRNA

Indexed as

CytokinesDNA, MitochondrialMacrophagesMutationAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCyclooxygenase 2FemaleImmunity, InnateInflammationInterferon-betaInterferon Regulatory Factor-3Interferon Type IInterleukin-1betaLipopolysaccharidesMalecGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCyclooxygenase 2CytokinesDNA, MitochondrialInterferon-betaInterferon Regulatory Factor-3Interferon Type IInterleukin-1betaIrf3 protein, mouseLipopolysaccharidesMembrane ProteinsNucleotidyltransferasesSting1 protein, mouseSTING ProteinTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID41266309
PMCPMC12635290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.