ArticleNPJ genomic medicine2025
Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.
Abstract read
In one paragraph
Article in NPJ genomic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Clinicopathologic and molecular predictors of survival in BRCA-deficient tubo-ovarian high-grade serous carcinoma.Nature communications · 2026Article
- Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA-deficient tubo-ovarian high-grade serous carcinoma.Research square · 2025Article
- Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population.British journal of cancer · 2025Article
- BeyondmedRxiv : the preprint server for health sciences · 2025Article
- Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer.npj aging · 2025Review
Corrections and comments
- Update of
Authors and funding
168 authors.
Daniel R Barnes *Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. drb54@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-3781-7570
Jonathan P Tyrer *Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3724-4757
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4591-1214
Goska LeslieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5756-6222
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4351-9326
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Amber M AeiltsDepartment of Internal Medicine, Division of Human Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8907-7853
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Nadine AndrieuInserm U1331, Paris, France.
Irene L AndrulisDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-4226-6435
Hoda Anton-CulverDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Adalgeir ArasonDepartment of Pathology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0480-886X
Banu K ArunDepartment of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Judith BalmañaHereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.ORCID http://orcid.org/0000-0002-0762-6415
Elisa V BanderaCancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.ORCID http://orcid.org/0000-0002-8789-2755
Rosa B BarkardottirDepartment of Pathology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland.
Lieke P V BergerUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-3185-559X
Amy Berrington de GonzalezClinical Cancer Epidemiology, Institute of Cancer Research, London, UK.
Pascaline BerthetDépartement de Biopathologie, Centre François Baclesse, Caen, France.
Katarzyna BiałkowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.ORCID http://orcid.org/0000-0001-8489-6665
Line BjørgeDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0002-0240-2770
Amie M BlancoCancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA.
Marinus J BlokDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-7935-5933
Kristie A BobolisCity of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA.
Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, Hannover, Germany.
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5738-6683
Henriett ButzDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.ORCID http://orcid.org/0000-0003-1664-409X
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Maria A CaligoSOD Genetica Molecolare, University Hospital, Pisa, Italy.
Ian CampbellCancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-7773-4155
Carmen CastilloHereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
Kathleen B M ClaesCenter for Medical Genetics, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0003-0841-7372
Sarah V ColonnaDepartment of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Linda S CookDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Laboratory Medicine, Institute of Oncology and Maria Sklodowska-Curie Cancer Center, Warsaw, Poland.
Miguel de la HoyaMolecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.ORCID http://orcid.org/0000-0002-8113-1410
Anna deFazioCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-0057-4744
Allison DePersiaCenter for Medical Genetics, Endeavor Health, Evanston, IL, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Jennifer A DohertyDepartment of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Susan M DomchekBasser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-9458-0282
Zakaria EinbeigiDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
D Gareth EvansGenomic Medicine, Division of Evolution and Genomic Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Manchester, UK.ORCID http://orcid.org/0000-0002-8482-5784
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-0494-2620
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Maria Cristina FotiImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.ORCID http://orcid.org/0009-0002-2307-5286
Eitan FriedmanSackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.ORCID http://orcid.org/0000-0002-6745-1733
Megan N FroneNational Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Patricia A GanzSchools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA.
Aleksandra Gentry-MaharajMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK.
Gord GlendonLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.ORCID http://orcid.org/0000-0002-3987-9580
Anna González-NeiraHuman Genotyping Unit-CeGen, Spanish National Cancer Research Centre, Madrid, Spain.
Mark H GreeneNational Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1852-9239
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Aliana Guerrieri-GonzagaDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0003-1915-1688
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6705-7624
Thomas V O HansenDepartment of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Holly R HarrisProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jan HaukeCenter for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-8236-4075
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Frans B L HogervorstFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David G HuntsmanBritish Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.
Evgeny N ImyanitovDepartment of Tumor Growth Biology, N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Louise IzattClinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-1258-4843
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.ORCID http://orcid.org/0000-0002-5650-0501
Paul A JamesParkville Familial Cancer Centre, Peter MacCallum Cancer Center and the Royal Melbourne Hospital, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-4361-4657
Ramunas JanaviciusState Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Esther M JohnDepartment of Epidemiology & Population Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Siddhartha KarCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Beth Y KarlanDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9451-2933
Catherine J KennedyCentre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-4465-5784
Lambertus A L M KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-2368-1326
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.ORCID http://orcid.org/0000-0002-0470-0309
Jolanta KupryjanczykDepartment of Pathology and Laboratory Medicine, Institute of Oncology and Maria Sklodowska-Curie Cancer Center, Warsaw, Poland.
Yael LaitmanThe Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Ofer LavieTechnion-Israel Institute of Technology, Haifa, Israel.
Kate LawrensonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women's Cancer Program at the Samuel Oschin Cancer Institute Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jenny LesterDavid Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA.
Fabienne LesueurInserm U1331, Paris, France.ORCID http://orcid.org/0000-0001-7404-4549
Carlos Lopez-PleguezuelosFundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain.ORCID http://orcid.org/0009-0000-8898-5710
Phuong L MaiMagee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Taymaa MayPrincess Margaret Cancer Center, Toronto, ON, Canada.
Iain A McNeishDivision of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-9387-7586
Usha MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK.ORCID http://orcid.org/0000-0003-3708-1732
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Francesmary ModugnoWomens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA.
Jennifer M MongioviDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
Marco MontagnaImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Kirsten B MoysichRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5053-0390
Finn C NielsenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Catherine NoguèsDépartement d'Anticipation et de Suivi des Cancers, Oncogénétique Clinique, Institut Paoli-Calmettes, Marseille, France.
Edit OláhDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9936-1599
Ana OsorioCentre for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain.ORCID http://orcid.org/0000-0001-8124-3984
Laura PapiDepartment of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, University of Florence, Florence, Italy.
Harsh PathakDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Celeste L PearceDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Inge S PedersenMolecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-9902-8040
Ana PeixotoDepartment of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.
Tanja PejovicDepartment of Obstetrics & Gynecology, Providence Medical Center, Medford, OR, USA.
Pei-Chen PengDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5004-4322
Beth N PeshkinLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-2997-4701
Paolo PeterlongoLaboratory of Hematology-Oncology, European Institute of Oncology IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0001-6951-6855
C Bethan PowellCancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA.
Darya ProkofyevaUfa University of Science and Technology, Ufa, Russia.
Miquel Angel PujanaProCURE, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
Paolo RadiceUnit of Predictive Medicine: Molecular Bases of Genetic Risk, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID http://orcid.org/0000-0001-6298-4111
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7684-3122
Gad RennertTechnion-Israel Institute of Technology, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
George RichenbergMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-6776-0018
Naoko SasamotoDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4526-2181
Veronica W SetiawanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Priyanka SharmaDepartment of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, USA.
Weiva SiehDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christian F SingerDept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Katie SnapeDeptartment of Clinical Genetics, South West Thames Centre for Genomics, St George's University Hospitals NHS Foundation Trust, London, UK.
Anna P SokolenkoDepartment of Tumor Growth Biology, N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Penny SoucyGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.ORCID http://orcid.org/0000-0002-6313-9005
Dominique Stoppa-LyonnetGenetics Department, Institut Curie, Paris, France.
Rebecca SutphenHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4051-5888
Yen Y TanDept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Manuel R TeixeiraDepartment of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center, Porto, Portugal.ORCID http://orcid.org/0000-0002-4896-5982
Kathryn L TerryDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Liv Cecilie V ThomsenDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.ORCID http://orcid.org/0000-0002-6787-8518
Marc TischkowitzDepartment of Genomic Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Amanda E TolandDepartment of Internal Medicine, Division of Human Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0271-1792
Toon Van GorpDivision of Gynecologic Oncology, University Hospital Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-2564-721X
Ana VegaFundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-7416-5137
Digna R Velez EdwardsDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Penelope M WebbPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QID, Australia.ORCID http://orcid.org/0000-0003-0733-5930
Jeffrey N WeitzelDivision of Precision Prevention, The University of Kansas Cancer Center, Kansas City, KS, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alice S WhittemoreDepartment of Epidemiology & Population Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Stacey J WinhamDepartment of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8492-9102
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Siddhartha YadavDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4630-9903
Yao YuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2727-1746
Argyrios ZiogasDepartment of Medicine, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-4529-3727
Andrew BerchuckDepartment of Gynecologic Oncology, Duke University Hospital, Durham, NC, USA.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ellen L GoodeDepartment of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9094-8326
Marc T GoodmanSamuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-8448-4801
Kenneth OffitClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Susan J RamusSchool of Clinical Medicine, Faculty of Medicine and Health, University of NSW Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-0005-7798
Harvey A RischChronic Disease Epidemiology, Yale School of Medicine, New Haven, CT, USA.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Québec City, QC, Canada.ORCID http://orcid.org/0000-0001-6906-3390
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Michelle R JonesCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Simon A GaytherCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7937-5443
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul D P PharoahDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8494-732X
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MUNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MNRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MSWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MStatistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam · 2014 to 2026
$146.4MGYNECOLOGIC ONCOLOGY GROUP HEADQUARTERSU10CA027469 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 1985 to 2013
$132.6MTwo-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6MTRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MCancer Research UK (CRUK) PPRPGM-Nov20\100002Cancer Research UK (CRUK) PRCPJT-May21\100006Intramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049033NCATS NIH HHS UL1 TR000124NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA080668NCI NIH HHS K07 CA095666NCI NIH HHS K22 CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC067010NCI NIH HHS N02 CP011019NCI NIH HHS N02 CP065504NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016520NCI NIH HHS P30 CA051008NCI NIH HHS P30 CA072720NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA125183NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA106414NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA116167NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA140323NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA160669NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS R01 CA214545NCI NIH HHS R01 CA248288NCI NIH HHS R01 CA260132NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R03 CA130065NCI NIH HHS R25 CA112486NCI NIH HHS R35 CA253187NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA070867NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA058860NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA161032NCI NIH HHS U01 CA164920NCI NIH HHS U01 CA164973NCI NIH HHS U10 CA027469NCI NIH HHS U10 CA037517NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U10 CA180888NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NCRR NIH HHS S10 RR025141NIGMS NIH HHS P20 GM130423Wellcome Trust
Abstract
Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3'-UTR SNP rs78378222-T's association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28-1.62, P = 1.76 × 10
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