Trial reportScientific reports2025
Effectiveness of a 52-week multidomain intervention to maintain cognitive function in patients with mild cognitive impairment: a randomized controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mild cognitive impairment (MCI) increases the risk of dementia. Reducing modifiable lifestyle-related risk factors can help prevent cognitive decline in patients with MCI. We examined whether a multidomain intervention using a mobile application can prevent cognitive decline in patients with MCI. The trial is designed in accordance with the CONSORT Statement. We conducted an assessor-blind, randomized controlled trial. Patients with MCI, aged over 60 years and presenting with at least one modifiable risk factor for dementia, were recruited from three dementia centers in Gangwon-do, Korea, and outpatient clinics at Chuncheon Sacred Heart Hospital. Participants were randomly assigned to either the intervention group or the control group in a 1:1 ratio. Each participant received a 52-week intervention. The intervention group used a mobile application to manage their diet and physical activity at least three times per week, while the control group received general dietary and physical activity recommendations twice a year. The primary outcome was the change in cognitive function measured based on the mini-mental state examination in the Korean version of the CERAD assessment packet (MMSE-KC) score. Between October 2020 and September 2021, 84 people were screened, and 80 participants were randomly assigned to either the control or intervention group (intervention group = 42, control group = 38). Participants in both groups underwent a post-baseline assessment and their data were included in the analysis. We found a positive effect of the multidomain intervention using a mobile application on the change in cognitive function score in the intervention group compared to the control group at the 52-week follow-up. The MMSE-KC (F = 10.6, p < .001) and modified Boston Naming test (F = 8.3, p < .01) scores were significantly higher in the intervention group than in the control group. The results suggest that a multidomain mobile application intervention could help improve cognition in patients with MCI.The study protocol was prospectively registered with the Clinical Research Information Service (CRIS, Republic of Korea; KCT0008315) on March 16, 2023. The full trial details can be accessed at https://cris.nih.go.kr/cris/search/detailSearch.do?seq=22920 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.