Evidence map›Paper›PMID 41266746›Full record

ArticleScientific reports2025

Synthesis and preliminary biological evaluation of quinoline-chrysin hybrids against head and neck squamous cell carcinoma.

Monika Kadela-Tomanek, Arkadiusz Sokal, Kamil Krzykawski, Marcel Madej, Robert Kubina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monika Kadela-TomanekDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec,, Medical University of Silesia in Katowice, 4 Jagiellońska Str, 41-200, Sosnowiec, Poland. mkadela@sum.edu.pl.
Arkadiusz SokalDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec,, Medical University of Silesia in Katowice, 4 Jagiellońska Str, 41-200, Sosnowiec, Poland.
Kamil KrzykawskiDoctoral School, Medical University of Silesia in Katowice, 15 Poniatowskiego Str, 40-055, Katowice, Poland.
Marcel MadejSilesia LabMed, Centre for Research and Implementation, Medical University of Silesia, in Katowice, 18 Medyków Str, 40-752, Katowice, Poland.
Robert KubinaSilesia LabMed, Centre for Research and Implementation, Medical University of Silesia, in Katowice, 18 Medyków Str, 40-752, Katowice, Poland.

Funding

Project European Funds for Silesia 2021-2027, entitled. "Supporting the transformation of the region by strengthening the potential of the Doctoral School of the Medical University of Silesia in Katowice" NWD/2464/2024
6 · The paper itself

Abstract

Chrysin belongs to natural flavonoids characterized wide spectrum of biological activity. Its use in treatment is limited by low bioavailability and rapid metabolism. The structure-activity relationship shows that introduction of substituent at C7 position of flavone scaffold increase the activity and bioavailability. In this study, a series of quinoline-chrysin hybrids was obtained. The structure of compounds was determined using spectroscopic methods. The anticancer activity of compounds was tested against neck and head squamous cell carcinoma lines (HNSCC), while the antioxidant activity was determined using DPPH method. The biological effect depends on the type of quinoline moiety. For the most active compounds, IC

Indexed as

Antineoplastic AgentsFlavonoidsHead and Neck NeoplasmsQuinolinesSquamous Cell Carcinoma of Head and NeckAntioxidantsCell Line, TumorHumansProto-Oncogene Proteins c-bcl-2Structure-Activity RelationshipTumor Suppressor Protein p53Antineoplastic AgentsAntioxidantschrysinFlavonoidsProto-Oncogene Proteins c-bcl-2quinolineQuinolinesTumor Suppressor Protein p53Antioxidant activityChrysinDPPHHead and neck cancerNMRQuinoline

Identifiers

PMID41266746
PMCPMC12635337

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.