ReviewNature reviews. Molecular cell biology2026
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance.
Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Biomolecular coacervation-mediated materials: Phase states, phase transitions, and biomedical applications.Bioactive materials · 2027Review
- How do low-complexity domain interactions control transcription?Biochemical Society transactions · 2026Review
- Probing biomolecular condensates with a minimally perturbative experimental readout framework.The Biochemical journal · 2026Review
- Optogenetic Evidence for the Intrinsic Phase Separation Propensity of the Sgs1 N-Terminal Region: Implications for Assemblysome Formation.Biomolecules · 2026Article
- Single Fluorogens and Orientation-Localization Microscopy for Quantifying Chemical and Biomolecular Dynamics at the Nanoscale.Accounts of chemical research · 2026Article
- A practical guide to investigating biomolecular condensates: a comment from the plant community.Science China. Life sciences · 2026Review
- A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- What is active wetting?The European physical journal. E, Soft matter · 2026Review
- Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases.Journal of nanobiotechnology · 2026Review
- Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- Pharmacological modulation of stress granulesFrontiers in pharmacology · 2026Review
- RanGAP1 accumulates in stress-induced cytoplasmic compartments that are distinct from stress granules and P-bodies.microPublication biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes, largely by enriching and excluding certain molecules. Emerging evidence demonstrates that condensate compositions dynamically change in response to stimuli and over time. Thus, condensates that share a designation and general function can substantially vary in their composition. In this Review, we discuss the current understanding of condensate composition changes and heterogeneity, how they are regulated and how the changes affect biochemical reactions. We focus on four condensates: DNA double-strand break (DSB) repair foci, promyelocytic leukaemia (PML) nuclear bodies, processing bodies (P-bodies) and RNA transport granules, with examples from stress granules and germ granules. Changes in condensate composition seem to support complex reactions, such as those occurring in DNA repair and RNA processing. Mechanisms regulating composition changes include biophysical features of components, modifications, nodes and enzymatic reactions. We also speculate about the impact of protein mislocalization and mutations on condensate composition and function, including in cancer and neurodegenerative diseases. We conclude by discussing outstanding questions and the implications of studying condensate composition changes for research and therapeutics.
Indexed as
Identifiers
41266895What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.