Evidence map›Paper›PMID 41266928›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

Dingchun Hou, Bo Liang, Kai Zhao, Ye Zhang, Minglang Lang, Zhiqin Xu, Hezhang Yun, Weijun Yang, Longqi Yu, Chang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dingchun HouBeijing Sport University, Beijing, China.
Bo LiangInstitute of Population Research, Peking University, Beijing, China.
Kai ZhaoBeijing Sport University, Beijing, China.
Ye ZhangBeijing Sport University, Beijing, China.
Minglang LangBeijing Sport University, Beijing, China.
Zhiqin XuBeijing Sport University, Beijing, China.
Hezhang YunSchool of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Jinhua, China.
Weijun YangBeijing Sport University, Beijing, China.
Longqi YuBeijing Sport University, Beijing, China.ORCID 0000-0002-9039-0289
Chang LiuBeijing Sport University, Beijing, China.ORCID 0000-0002-7867-6807

Funding

Applied Research in the Intersection of Sport an Dance BSU20240129Beijing Higher Education Society's Sub-Committee on University Student Employment and Entrepreneurship Research under the project titled "Research on the Transformation Path and Mechanism of Innovation and Entrepreneurship Competition Achievements among University Students-Based on the Practice of Sports Universities" DXSJCFHMS2025023High-Quality Development Cultivation Program of the Beijing Sport University 2024SKPY18National Teams Science and Technology Support Program for Youth of the General Administration of Sport of China 24QN017Peking University Health Science Center for the Study on the effects of anti-aging nutritional interventions on athletes' skin health BSU20240500Peking University Health Science Center for the Study on the effects of anti-aging nutritional interventions on athletes' skin health YFF24000662Peking University Medical-Qingyan Boshi Joint Laboratory for skin nutrition and anti-aging L202206
6 · The paper itself

Abstract

backgroundCurrent evidence indicates an association between peak expiratory flow (PEF) and frailty in older adults, yet critical gaps persist regarding: the longitudinal dynamics of PEF trajectories, their temporal relationships with frailty progression and underlying biological mechanisms. This study aimed to investigate the associations of baseline PEF and its longitudinal trajectories with incident frailty risk, while elucidating potential mechanistic pathways in older adults.

methodsA prospective cohort study was conducted of general community-dwelling adults aged ≥ 65 years from 2006 to 2022 in the Health and Retirement Study from the United States. PEF trajectories were identified using group-based trajectory modelling. Frailty was assessed by the Fried frailty phenotype, encompassing five key components: weight loss, exhaustion, physical activity, gait speed and grip strength. Participants were classified as frailty if they met three or more. Cox proportional hazard models were applied to estimate the associations.

resultsA total of 5686 participants with a median age of 72.5 (interquartile range: 68-77) years and 3262 (57.37%) females were included and followed up for 34 052 person-years with an incidence density of frailty of 31.69 per 1000 person-years. The proportion of White, Black and other ethnic populations was 83.45%, 12.56% and 3.99%, respectively. Compared with participants in the Q

conclusionsLow PEF over both short and extended periods was significantly associated with an increased risk of frailty in older adults. These findings highlight the importance of monitoring pulmonary function as a potential marker for frailty risk and suggest that PEF may influence different frailty phenotypes to varying extents.

Indexed as

FrailtyAgedAged, 80 and overFemaleFrail ElderlyHumansMalePeak Expiratory Flow RateProspective Studiesfrailtypeak expiratory flowprospective cohorttrajectory

Identifiers

PMID41266928
PMCPMC12641449

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.