ReviewOral diseases2026
Early Childhood Caries in Preschool Children: A Multidimensional Analysis From Biological Mechanisms to Socioecological Interventions.
Review in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo analyze the "technology-disease burden paradox" of early childhood caries (ECC)-its rising global prevalence despite preventive advances-by examining multidimensional factors from biological mechanisms to socioecological interventions.
methodsThis narrative review synthesized evidence from epidemiological, biological, behavioral, and policy studies (2010-2024) identified through systematic searches in PubMed, Web of Science, and Scopus. Inclusion criteria focused on children under 6 years of age and English-language studies reporting etiology, risk factors, or interventions.
resultsECC prevalence exceeds 60% in many low- and middle-income countries, versus < 40% in high-income settings. Key findings include: synergistic enamel demineralization by S. mutans and Candida (OR = 1.67); behavioral risks such as nocturnal feeding (OR = 3.54) and screen time > 2 h/day (↑60% caries); and effective policy interventions like fluoride varnish (42% reduction in caries) and sugar taxes.
conclusionsControlling ECC requires integrating the Socioecological Model with Sustainable Development Goals, prioritizing equity-focused upstream policies and interdisciplinary collaboration (e.g., dentistry and data science). The "Zero-Caries Childhood" vision must shift from disease management to health promotion, incorporating emerging environmental considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.