Evidence map›Paper›PMID 41266979›Full record

ArticleThe journal of headache and pain2025

Selective vulnerability of GABAergic neurons in chronic migraine.

Kazi Helal Hossain, Timothy Chuong, Emily Abad, Justin Lin, Chenchen Xia, Meng Li, Yibu Chen, Xianghong Arakaki, Anju Vasudevan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kazi Helal HossainAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Timothy ChuongAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Emily AbadAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Justin LinAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Chenchen XiaCognition and Brain Integration Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Meng LiUSC Libraries Bioinformatics, University of Southern California (USC), Health Science Campus, 2003 Zonal Ave, Los Angeles, CA, 90089, USA.
Yibu ChenUSC Libraries Bioinformatics, University of Southern California (USC), Health Science Campus, 2003 Zonal Ave, Los Angeles, CA, 90089, USA.
Xianghong ArakakiCognition and Brain Integration Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA. xianghong.arakaki@hmri.org.
Anju VasudevanAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA. anju.vasudevan@hmri.org.

Funding

Dysfunction of Sodium Homeostasis in MigraineR01NS072497 · NINDS · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI ARAKAKI, XIANGHONG, GRANT, SAMUEL COLLES · 2011 to 2023
$4.8M
Novel Developmental Pathways Underlying Psychiatric DisordersR01MH110438 · NIMH · MCLEAN HOSPITAL · PI Anju Vasudevan · 2016 to 2026
$4.7M
Shared Resource in Cellular ImagingS10MH133643 · NIMH · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI VASUDEVAN, ANJU · 2023 to 2023
$283k
National Institute of Aging, United States R01NS072497NIMH NIH HHS R01 MH110438NIMH NIH HHS R01MH110438, S10MH133643NIMH NIH HHS S10 MH133643NINDS NIH HHS R01 NS072497
6 · The paper itself

Abstract

backgroundMigraine is the second leading cause of neurological disability and has a strong genetic component. Previous linkage studies have identified a candidate migraine susceptibility locus on chromosome Xq24-28, which harbors several GABA

resultsNotably, a selective reduction in GABAergic neurons was observed in male, but not female, NTG-treated mice, specifically within key brain regions associated with pain processing and psychiatric circuits, from the locus coeruleus in the brainstem through the basal forebrain (notably the amygdala) to the neocortex and hippocampus. This loss of GABAergic neurons was accompanied by elevated expression of ΔFosB, a marker of sustained neuronal activation, and increased apoptotic signaling indicated by active caspase-3 staining. Furthermore, male chronic migraine mice showed upregulation of stress-related neuropeptides, including PACAP and its receptor PAC1, as well as downstream effectors BDNF and TRK1B. Gene expression analysis revealed downregulation of GABA signaling components in the choroid plexus of the fourth ventricle, including aberrant overexpression of the chloride cotransporter NKCC1.

conclusionThese findings reveal a male-specific vulnerability of GABAergic neurons in chronic migraine and suggest a sex-dependent divergence in the underlying pathophysiological mechanisms. This highlights the critical need for sex-specific approaches to migraine research and therapeutic development.

Indexed as

BrainGABAergic NeuronsMigraine DisordersAnimalsChronic DiseaseDisease Models, AnimalFemaleHyperalgesiaMaleMiceMice, Inbred C57BLNitroglycerinNitroglycerin

Identifiers

PMID41266979
PMCPMC12636155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.