Evidence map›Paper›PMID 41267164›Full record

ArticleInternational wound journal2025

Ozoile-Stable Ozonides, Derived From Organic Extravirgin Olive Oil, Enhance Wound Healing Process in Patients With Diabetic Chronic Ulcers.

Barbara De Angelis, Fabrizio Orlandi, Margarida Fernandes Lopes Morais D'Autilio, Stefano Mogavero, Ruggiero Marrano, Lorenza Marconi, Leonardo Palombi, Giovanna Scioli Maria, Augusto Orlandi, Paolo De Ninis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Barbara De AngelisDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Fabrizio OrlandiDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Margarida Fernandes Lopes Morais D'AutilioDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Stefano MogaveroDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Ruggiero MarranoDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Lorenza MarconiDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
Leonardo PalombiDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
Giovanna Scioli MariaDepartment of Anatomopathology, Tor Vergata University of Rome, Rome, Italy.
Augusto OrlandiDepartment of Anatomopathology, Tor Vergata University of Rome, Rome, Italy.
Paolo De Ninis"Luisa D'Annunzio" Institute for High Culture, Pescara, Italy.
Lorenzo SecondiDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Valerio CervelliDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Pietro GentileDepartment of Surgical Science, Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The article describes the outcomes of a single-centre investigation on the use of OZOILE to improve the healing process in patients with chronic diabetic ulcers. This is a non-randomised interventional study which aims to assess the differences between two groups (total 200 patients) by evaluating healing time at 15, 30, 45, 60, 75 and 90 days. Pain assessment with VAS scale at 15, 30 and 45 days, biofilm test and tissue regeneration by histological evaluation were also taken into consideration. The outcomes show faster healing, reduced pain, control of local infection, aesthetically pleasing and qualitatively better healing. Our treatment strategy involves applying OZOILE detergent without rinsing, Ozoile spray oil and Ozoile cream followed by a non-adherent dressing (paraffin gauze). This integrated protocol shows a safe and effective treatment for diabetic chronic wound healing in a cost-effective manner. The group treated with the Rigenoma/Ozoile protocol demonstrated significantly superior outcomes compared to the control group, including accelerated healing, reduced pain levels, effective management of unpleasant odour, and high levels of compliance from both patients and surgeons. Overall, Ozoile markedly reduced healing time compared with standard care, with results robust across multiple analytical approaches.

Indexed as

Diabetic FootOlive OilWound HealingAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedTreatment OutcomeOlive Oildiabetic chronic ulcersextra virgin olive oilozone therapyozonised oilwound care

Identifiers

PMID41267164
PMCPMC12634472

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.