Evidence map›Paper›PMID 41267352›Full record

ArticleThe Journal of organic chemistry2025

Iridium-Catalyzed Direct and Site-Selective C-H Heteroarylation, Alkenylation, and Alkylation of Indoles.

Tian Cao, Wanqi Hu, Linlu Hao, Liting Guo, Li Wu, Lei Xu, Zhaobing Gao, Jia Li, Fuyun Tian, Xiaowei Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tian CaoZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Wanqi HuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Linlu HaoZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Liting GuoZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Li WuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Lei XuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Zhaobing GaoZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.ORCID 0000-0001-8931-5508
Jia LiZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Fuyun TianZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Xiaowei WuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.ORCID 0000-0001-7248-9149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indoles and coumarins represent prominent structural motifs in a wide range of biologically active molecules. Combining these two privileged scaffolds offers immense potential for innovation in drug discovery. Herein, we unveil a regioselective iridium-catalyzed approach for the direct C-H heteroarylation, alkenylation, and alkylation of indoles using iodonium ylides through a metal carbene-induced C-H insertion mechanism, accessing a series of novel 4-hydroxy-3-indolyl-coumarins and analogues. The method demonstrates a wide substrate scope, good tolerance for functional groups, scalability with low catalyst loading (as low as 0.2 mol %), and mild reaction conditions. Notably, Compound

Indexed as

IndolesIridiumAlkylationCatalysisCell Line, TumorHumansMolecular StructureIndolesIridium

Identifiers

PMID41267352
PMCPMC12690593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.