ReviewFrontiers in neuroscience2025
The multi-pathway treatment of flavonoids as natural compounds in neurological diseases: achievements, limitations, and prospects.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- In Vitro Cell Viability and Migration Inhibitory Effects of Isorhamnetin in Non-Small Cell Lung Cancer Cells.Biomedicines · 2026Article
- Targeting Reactive Astrocytes with Flavonoids to Alleviate Neuroinflammation and Promote Synaptic Function.Molecular neurobiology · 2026Review
- Artificial Intelligence for Natural Products Drug Discovery in Neurodegenerative Therapies: A Review.Biomolecules · 2026Review
- Flavonoids in Plants and Human Health: From Biosynthesis to Neurodevelopmental and Neurodegenerative Disorders.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The nervous system governs fundamental life activities and higher neural functions, maintaining the body's interaction with the external environment and internal homeostasis. Neurological diseases are a common and complex group of disorders that severely impair patients' quality of life and physical health. Flavonoids, as a class of active components widely present in natural plants, play a crucial role in the research on neurological diseases. Objective: The purpose of this review is to systematically sum up the action mechanisms, research advancements, and existing clinical uses of flavonoids in preventing and treating neurological diseases, probing into their potential in the management of neurological diseases. Methods: By searching databases including PubMed, Web of Science, Embase, Wiley, Springer, NPG, ACS, Elsevier, and RSC, literature published between 2000 and 2025 concerning the treatment of neurological diseases with flavonoids was collected from both domestic and international sources. Priority should be given to flavonoids that have been confirmed by existing studies to be directly related to the pathogenesis or intervention effect of neurological diseases, with high quality and no contradictory results, clear chemical structures and definite metabolic pathways Results: Flavonoids can exert neuroprotective effects in the prevention and treatment of neurological diseases through multiple pathways, such as anti-inflammation, anti-oxidation, anti-apoptosis, and neurotransmitter regulation. Conclusion: Flavonoids exhibit clear pharmacological effects and favorable safety profiles in the prevention and treatment of neurological diseases, laying a foundation for the research and development of new drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.