ReviewFrontiers in medicine2025
Liquid biopsy in orthopedic trauma: exosomes as functional mediators and mechanistic indicators in post-traumatic complications.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Severe orthopedic trauma initiates complex pathophysiological cascades that frequently lead to life-threatening complications including acute compartment syndrome, fat embolism syndrome, deep vein thrombosis, and fracture non-union. Traditional biomarkers provide only retrospective indicators of tissue damage, lacking the sensitivity and specificity needed for early complication detection. Exosomes, nanoscale extracellular vesicles carrying proteins, lipids, and nucleic acids, have emerged as critical mediators of intercellular communication that actively participate in trauma pathophysiology. This comprehensive review synthesizes accumulating evidence suggesting that exosomes may function as active mediators rather than passive biomarkers in orthopedic trauma complications. Studies demonstrate that trauma-derived exosomes transfer functional cargo including miR-155 and inflammatory proteins that reprogram recipient cell phenotypes and induce endothelial dysfunction.
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