ReviewFrontiers in oncology2025
CricRNA in head and neck squamous cell carcinoma: biological functions and clinical prospects.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding the role of non-coding RNAs in HNSCC radioresistance: molecular mechanisms and clinical implications.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally, shows an unfavorable prognosis and has a five - year survival rate lower than 50%. Circular RNA (circRNA) is defined as a type of non-coding RNA molecule that forms a covalently closed circular structure through back-splicing, characterized by tissue specificity, high stability, and stability in body fluid detection. Recent research has frequently revealed marked alterations in circRNA regulation in HNSCC and participates in tumor malignant behaviors such as cell proliferation and apoptosis, invasion and metastasis, epithelial-mesenchymal transition (EMT), chemoresistance, and immune evasion through mechanisms like "miRNA sponges," protein scaffolding, translation templates, and epigenetic regulation. This review aims to provide a systematic and up-to-date consolidation of the latest advances in circRNA research for HNSCC, from its biogenesis and multifaceted functions to clinical translation. Our goal is to uncover novel biomarkers and therapeutic targets for the precise diagnosis and management of HNSCC. This review not only aids in elucidating the complex regulatory networks orchestrated by circRNAs in HNSCC but also highlights their immense potential as novel diagnostic and therapeutic agents, thereby paving the way for future research and clinical application.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.