Evidence map›Paper›PMID 41268092›Full record

ArticleEJHaem2025

Paroxysmal Nocturnal Hemoglobinuria in Pregnancy Treated With Pegcetacoplan: Case Report and Pharmacokinetic Analysis.

Benjamin Chin-Yee, Benjamin D Hedley, Rui Su, Barbra de Vrijer, Facundo Garcia-Bournissen, Sarah Parkinson, Cyrus C Hsia, Matthew Nichols, Ian Chin-Yee, Christopher J Patriquin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The varieties of therapeutic experience: navigating treatment options for patients with PNH.Hematology. American Society of Hematology. Education Program · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin Chin-YeeDepartment of Pathology and Laboratory Medicine Western University London Ontario Canada.
Benjamin D HedleyDepartment of Pathology and Laboratory Medicine Western University London Ontario Canada.
Rui SuDepartment of Pathology and Laboratory Medicine London Health Sciences Centre London Ontario Canada.
Barbra de VrijerDepartment of Obstetrics and Gynecology Western University London Ontario Canada.
Facundo Garcia-BournissenDivision of Pediatric Clinical Pharmacology Department of Pediatrics Western University London Ontario Canada.
Sarah ParkinsonDepartment of Obstetrics and Gynecology Western University London Ontario Canada.
Cyrus C HsiaDepartment of Pathology and Laboratory Medicine Western University London Ontario Canada.
Matthew NicholsDepartment of Pathology and Laboratory Medicine Western University London Ontario Canada.
Ian Chin-YeeDepartment of Pathology and Laboratory Medicine Western University London Ontario Canada.
Christopher J PatriquinDivision of Hematology University Health Network, University of Toronto Toronto Ontario Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an unmet clinical need for effective treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pregnancy for patients with inadequate response to C5 inhibitors. We report the first case of pegcetacoplan use in pregnancy with accompanying pharmacokinetic analysis. In a patient with transfusion-dependent anemia on eculizumab, third-trimester initiation of pegcetacoplan led to hematological stabilization, transfusion independence, and an uncomplicated term cesarean delivery of a healthy infant. Pegcetacoplan was undetectable in cord blood and breast milk despite therapeutic maternal levels, suggesting fetal and neonatal safety due to lack of significant placental and lactational transfer, and advancing evidence for pegcetacoplan use in pregnancy.

Indexed as

case reportparoxysmal nocturnal hemoglobinuriapegcetacoplanpharmacokineticpregnancy

Identifiers

PMID41268092
PMCPMC12628701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.