Trial reportTopics in spinal cord injury rehabilitation2025
Vitamin D Supplementation Adjunct to Home-Based Electrical Stimulation Exercise Program Versus Passive Movement Training in Chronic SCI: Individual Results From Trial Under Accrual.
Trial report in Topics in spinal cord injury rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Trial
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Background: Neurogenic osteoporosis as a result of bone demineralization is a well-known complication after spinal cord injury (SCI). Bone demineralization is a result of the inevitable mechanical unloading of paralyzed limbs and decreased skeletal muscle activity. Objectives: To determine the impact of a home-based electrical stimulation (ES)-induced exercise (Excs) protocol plus 2000 IU oral daily vitamin D (vit D) supplementation compared to passive movement training (PMT) plus 2000 IU oral daily vit D supplementation on bone microarchitectural properties as measured by magnetic resonance imaging (MRI), bone mineral density (BMD) as measured by dual-energy x-ray absorptiometry (DXA), and biomarkers of bone formation and bone resorption in persons with chronic SCI. Methods: Six men with motor complete SCI ranging from C8 to T10 were randomized into either 9 months of vit D+ES-Excs or vit D+PMT groups. The vit D+ES-Excs group underwent daily supplementation of vit D with 4.5 months of neuromuscular electrical stimulation-resistance training (NMES-RT) followed by 4.5 months of functional electrical stimulation (FES) rowing, twice weekly, using a home-based training approach. MRI, DXA, and blood biomarkers were captured at the beginning of the study (baseline), 4.5 months (post-intervention 1), and 9 months after training (post-intervention 2). Results: The percentage changes indicated that 2 persons in the vit D+ES-Excs group showed decreases in trabecular spacing (28%) and increases in trabecular network (33%-49% at post-intervention 2). This was accompanied by attenuation of BMD loss at the pelvis (3.6%-7.7%), femoral necks (4.5%-8.4%), and knees (10.5%-18.7%). The vit D+ES-Excs group showed increases in leg (5.3%) to total body lean mass and decreases in biomarkers of bone resorption (7.0%-23.5%). Similar changes were not demonstrated following 9 months of vit D+PMT. Conclusion: Home-based training with 9 months of vit D+ES exercise demonstrated the safety and practicability in mitigating deleterious changes in bone health in persons with chronic SCI. This is concomitant with increased leg lean mass and decreased circulating biomarkers of bone resorption in persons with SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.