ArticleFrontiers in human neuroscience2025
Spontaneous neural activity changes in minimal hepatic encephalopathy before and 1 month after liver transplantation.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Advances in Multimodality Monitoring in Traumatic Brain Injury.Current neurology and neuroscience reports · 2026Review
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7 authors.
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Abstract
Minimal hepatic encephalopathy (MHE) is the initial stage of hepatic encephalopathy (HE), MHE patients have associated with widespread neuro-psychological impairment. Liver transplantation (LT) can restore metabolic abnormalities but the mechanisms are unclear. This study aimed to longitudinally evaluate brain function alteration in MHE patients one month after LT and their correlation with cognitive changes by using resting-state functional magnetic resonance imaging (rs-fMRI). Rs-fMRI data was collected from 32 healthy controls and 27 MHE before and 1 month after LT. Between-group comparisons of demographic data and neuropsychological scores were analyzed using SPSS 25.0. Functional imaging data were analyzed using RESTplus and SPM12 software based on MATLAB 2017b. Gender, age, and years of education were used as covariates to obtain low-frequency fluctuationd (ALFF) and dynamic low-frequency fluctuation (dALFF) dindices. Correlation analyses were performed to explore the relationship between the change of ALFF and dALFF with the change of clinical indexes pre- and post-LT. Compared to controls, ALFF values increased in the Left Cerebelum 8, right orbital part of the inferior frontal gyrus (ORBinf), right superior occipital gyrus (SOG) and decreased in right PreCG and left middle frontal gyrus (MFG) in patients post-LT; dALFF values increased in the right temporal pole and middle temporal gyrus (TPOmid), right ORBinf, left caudate nucleus (CAU), right SOG and decreased in left PreCG, left PCUN, left ANG, left SMA and left MFG in patients post-LT. Compared to pre-LT, ALFF values of post-LT patients increased in the right calcarine fissure and surrounding cortex (CAL), right MOG and decreased in right cerebelum 8, left PCUN; dALFF values of post-LT patients decreased in right thalamus (THA), left posterior cingulate gyrus (PCG) and left MFG. The changes of ALFF in the left PCUN, right CAL and right MOG were correlated with change of digit symbol test (DST) scores (
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