Evidence mapPaperPMID 41268178Full record

ArticleBrain communications2025

Sleep-related changes in astrocytic biomarkers are modulated by

Nuole Zhu, Miren Altuna, Javier Arranz, Íñigo Rodriguez-Baz, Maria Belén Sanchez-Saudinós, Laura Videla, Sílvia Valldeneu, Mireia Carrera-Vega, Sergio Romero, Juan Fortea and 3 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nuole ZhuSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.ORCID https://orcid.org/0000-0002-0015-9455
Miren AltunaCITA-Alzheimer Foundation, Donostia-San Sebastián 20009, Spain.ORCID https://orcid.org/0000-0001-9709-5314
Javier ArranzSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Íñigo Rodriguez-BazSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Maria Belén Sanchez-SaudinósSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Laura VidelaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Sílvia ValldeneuSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Mireia Carrera-VegaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Sergio RomeroAutomatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya-BarcelonaTech (UPC), BarcelonaTech (UPC), Barcelona 08005, Spain.
Juan ForteaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.ORCID https://orcid.org/0000-0002-1340-638X
Alberto LleóSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.
Sandra GiménezSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.ORCID https://orcid.org/0000-0001-8031-2319
Daniel AlcoleaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain.ORCID https://orcid.org/0000-0002-3819-3245

Funding

NIA NIH HHS R21 AG056974NIA NIH HHS RF1 AG056850NIA NIH HHS RF1 AG061566
6 · The paper itself

Abstract

Astrocytes are key regulators of sleep and neuroinflammatory responses. However, the relationship between objective sleep parameters and astrocytic fluid biomarkers in cognitively unimpaired individuals remains unclear. We examined how sleep architecture relates to astrocytic, neuroaxonal and Alzheimer's disease-related fluid biomarkers in cognitively unimpaired adults and whether age, sex and

Indexed as

Alzheimer’s disease-related proteinsapolipoprotein ε4astrocytescognitively unimpaired individualpolysomnography

Identifiers

PMID41268178
PMCPMC12629230

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.