ArticlePCN reports : psychiatry and clinical neurosciences2025
Brain iron distribution in transdiagnostic mental health burden.
Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review.Early intervention in psychiatry · 2026Review
- Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psychiatric diseases are increasingly understood as a spectrum or continuous phenomena, ranging from healthy to severely affected, yet neurobiological correlates for these dimensions remain elusive. Regional alteration of iron levels in the central nervous system may reflect neuropathological processes that result in significant impairment of cognitive and behavioral functions. The aim of this study was to characterize brain iron distribution in individuals with common clinical psychiatric disorders and offspring of individuals affected by these disorders. Methods: R2* magnetic resonance imaging (MRI) based multi-parameter mapping (MPM) algorithm was used to assess regional brain iron distribution in a) individuals diagnosed with bipolar disorder (BD), borderline personality disorder (BPD), attention-deficit/hyperactivity disorder (ADHD), and offspring ( Results: Three distinct clusters of regional brain iron distribution were found, differentiating patients and patient offspring from healthy controls and control offspring with 94% sensitivity (OR: 8.9; Conclusion: Our finding of a characteristic brain iron distribution pattern in individuals diagnosed with BD, BPD, and ADHD and offspring of diagnosed individuals supports that brain iron patterns may serve as neurobiological correlates for psychiatric disorders conceptualized as spectrum conditions. Further, longitudinal studies are needed to confirm whether pattern analysis of brain iron distribution may represent a transdiagnostic biomarker for a better understanding of underlying neuropathology in psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.