Evidence map›Paper›PMID 41268525›Full record

ArticleFrontiers in cardiovascular medicine2025

Plasma interferon predicts pulmonary hypertension severity and outcome.

Zhanping Liang, Yun Li, Shuying Jia, Yuyan Liu, Jie Zhu, Jinling Li, Fei Li, Xiaohuan Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhanping LiangCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Yun LiCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Shuying JiaDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuyan LiuDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jie ZhuCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
Jinling LiDepartment of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Fei LiDepartment of Radiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaohuan XiaCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary hypertension (PH) is a complex and progressive disease characterized by elevated pulmonary vascular resistance. Inflammation plays an important role in the pathogenesis of PH. Interferons (IFNs) are key immune cytokines that regulate cellular responses to various stimuli. This study aimed to investigate the association between IFN levels and the risk and prognosis of PH. Methods: A cohort of 875 PH patients and 182 matched controls were included in this study. Logistic regression models and receiver operating characteristic (ROC) curves were applied to evaluate the association between IFN levels and PH risk. Correlations between variables were assessed using Spearman's rank correlation coefficient (r ). Cox proportional hazards regression and Kaplan-Meier survival curves were used to assess the prognostic value of IFNs levels. The predictive performance of prognostic models was assessed using ROC analysis and decision curve analysis and a nomogram was constructed to estimate individual overall survival probabilities. Results: Both IFN-α and IFN-γ levels were significantly elevated in PH patients compared with controls ( Conclusions: These findings suggest that plasma IFN-α may serve as a valuable biomarker for both predicting PH risk and assessing prognosis.

Indexed as

inflammationinterferonprognosispulmonary hypertensionrisk factor

Identifiers

PMID41268525
PMCPMC12626927

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.