ArticleFrontiers in cell and developmental biology2025
A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Single-Cell Omics Advances in Understanding Tissue Development and Complex Trait Formation in Sheep and Goats.Animals : an open access journal from MDPI · 2026Review
- Advances in Single-Cell Transcriptomics for Livestock Health.Veterinary sciences · 2026Review
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Authors and funding
3 authors.
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Abstract
To explore the molecular mechanism of hair follicle apoptosis in the goat hair cycle, single-cell transcriptome sequencing was performed on 8,214 hair follicle cells in the Anagen period, Catagen period, and Telogen period. We identified nine cell types and found that Matrix cells (MCs) enriched the Wnt signaling pathway and apoptosis-related genes. Further studies revealed the key dynamic genes (such as KRT19, API5) and regulatory factors (such as MSX2, LEF1) that determine the fate of MCs. This study mapped a high-resolution cell map of goat hair follicle apoptosis, providing new insights and diagnostic biomarkers for programmed cell death.
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