Evidence map›Paper›PMID 41269061›Full record

ArticleACS chemical neuroscience2025

In Vitro Pharmacology of Mitragynine at α-Adrenoceptors.

Yiming Chen, Jordan Seto, Samuel Obeng, Marco Mottinelli, Sushobhan Mukhopadhyay, Richa Tyagi, Aidan J Hampson, Christopher R McCurdy, Lance R McMahon, Nader H Moniri and 1 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Atypical respiration patterns of kratom alkaloids.The Journal of pharmacology and experimental therapeutics · 2026
    Article
  2. Indole Alkaloids as Biased Opioid Receptor Modulators.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiming ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.
Jordan SetoDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.
Samuel ObengDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, United States.ORCID 0000-0002-9644-0750
Marco MottinelliDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-5725-0439
Sushobhan MukhopadhyayDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Richa TyagiDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.ORCID 0009-0001-9228-6311
Aidan J HampsonDivision of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, United States.
Christopher R McCurdyDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8695-2915
Lance R McMahonDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, United States.
Nader H MoniriDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.
Clinton E CanalDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, Georgia 30341, United States.ORCID 0000-0002-7940-933X

Funding

Opioid use disorders: UF Pharmacy medications discovery and developmentUH3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2021 to 2023
$4.5M
Opioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6M
Nicotine dependence: neuropharmacology in monkeysR01DA025267 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MCMAHON, LANCE R. · 2009 to 2018
$3.4M
NIDA NIH HHS R01 DA025267NIDA NIH HHS UG3 DA048353NIDA NIH HHS UH3 DA048353
6 · The paper itself

Abstract

Mitragynine is a psychoactive alkaloid in

Indexed as

Receptors, Adrenergic, alpha-2Secologanin Tryptamine AlkaloidsAnimalsCHO CellsHEK293 CellsHumansRatsSignal TransductionmitragynineReceptors, Adrenergic, alpha-2Secologanin Tryptamine Alkaloidsalpha1alpha2clonidinemitragynineα1-adrenoceptorα2-adrenoceptor

Identifiers

PMID41269061
PMCPMC12679550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.