Evidence mapPaperPMID 41269276Full record

ReviewCellular and molecular life sciences : CMLS2025

Circular RNAs and endothelial dysfunction: mechanistic crosstalk and emerging therapeutic perspectives.

Zaheer Ud Din, Jing Xia, Zhu-Guo Wu, Zhaofu Liao, Xing-Dong Xiong

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zaheer Ud DinGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China.
Jing XiaGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China.
Zhu-Guo WuGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China.
Zhaofu LiaoGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China. liaozhaofu@gdmu.edu.cn.
Xing-Dong XiongGuangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, P.R. China. xiongxingdong@gdmu.edu.cn.ORCID http://orcid.org/0000-0003-4956-0917

Funding

Guangdong Provincial Introduction of Innovative Research and Development Team 2021KCXTD049Innovative Research Group Project of the National Natural Science Foundation of China 82071576
6 · The paper itself

Abstract

The dysfunction of endothelial cells (ECs) plays an essential role in the pathogenesis and development of a wide range of complex human diseases. These cells are important for regulating the functions of capillaries. Alterations in the vascular endothelium are associated with a broad spectrum of diseases, including atherosclerosis, stroke, hypertension, diabetes, coronary artery disease (CAD), venous thrombosis, cancer, and related angiogenesis disorders. Consequently, impaired endothelial function is recognized as a characteristic feature of numerous human diseases. circular RNAs (circRNAs) have recently expanded recognition as critical contributors to cellular processes, and their potential implications in endothelial dysfunction-related diseases have gained interest. While studies have extensively explored the roles of non-coding RNAs in endothelial dysfunction-related disease, the understanding of circRNAs in this context remains unclear. In this review, we aim to shed light on the mechanisms of circRNAs and their effect on endothelial dysfunction-related diseases. The investigation of circRNAs in endothelial dysfunction-related diseases such as atherosclerosis, hypertension, diabetes, and CAD holds great promises for uncovering innovative insights into disease pathogenesis and developing novel therapeutic approaches.

Indexed as

Endothelial CellsEndothelium, VascularRNA, CircularAnimalsAtherosclerosisCoronary Artery DiseaseDiabetes MellitusHumansRNA, CircularAgingAtherosclerosisCellular senescenceInflammationMyocardial fibrosisncRNAs

Identifiers

PMID41269276
PMCPMC12748457

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.