Trial reportEuropean journal of nuclear medicine and molecular imaging2026
Is
Trial report in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of FDG PET-CT Estimated Testis Functional Value Between Patients Having Positive Testicular Sperm Cells Extraction and Patients With a Negative Extraction, in Men With Azoospermia
Evaluate the Long-term (3 Months) Efficacy of L-threo DOPS (DroxiDopa) on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With Multiple System Atrophy (MSA). Comparative Study Versus Placebo
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeProspective multicenter trial to assess if testicular 18 F-FDG uptake with PET/CT is correlated with the positivity rate of the surgical sperm extraction procedure (TESE), which has only a success rate of about 50%, in men with azoospermia.
methodsMen with secretory azoospermia (SA), with excretory azoospermia (EA) and with normal spermogram (C) were included from february 2014 to may 2020. The baseline FDG PET/CT parameters that included peak, maximum and mean standardized uptake value and the functional testicular volume (FTV) were correlated with the TESE positivity and the standard clinical work up and the hormonal work up (FSH and inhibin and testosterone). A bivariate analysis was performed for the comparison between the two groups (positive or negative biopsy) and for the comparison between SA, EA and C with a significance level of 5%.
resultsThe study included 84 SA, 26 EA and 25 C. TESE was positive for 51 of the 97 men (53.13%). There was a significant correlation between the FTV and the positivity of TESE as well as with the FSH and inhibin and not with testosterone. The sum and the averaged FTV is significantly different between the three groups (SA, EA and C). FTV is significantly different from the testicular volume as determined via ultrasound (US) or CT. We found no significant correlation or difference for the intensity or the heterogeneity of FDG testicular uptake.
conclusionFTV obtained via PET/CT FDG is correlated with positivity of TESE in azoospermic men and is significantly different between the 3 groups ( EA, SA and C) and with the testicular volumes as obtained with US or CT. Furthermore, FTV is correlated with FSH and inhibin, which are parameters of the spermatogenesis and not with testosterone, a parameter of the steroidogenesis.
Indexed as
Identifiers
41269291What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.