ArticleSports medicine - open2025
Acute and Chronic Effects of a High-Intensity Interval Training Shock Microcycle on Cell-Free DNA: A Randomized Controlled Trial.
Article in Sports medicine - open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067426 (The 10/7 HIIT Shock Cycle Study), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The 10/7 HIIT Shock Cycle Study: The Effects of a 7-Day High-Intensity-Interval Training Shock Microcycle on Endurance Performance, Well-Being, Stress and Recovery in Endurance Trained Athletes - Randomized Controlled Trial
Who cites it
2 citing papers in PubMed.
- The effectiveness of polarized versus high-intensity training in moderately trained cyclists: a randomized parallel-design study.European journal of applied physiology · 2026Article
- Biomarkers as Temporal Signals: A Decision-Linked Multi-Layer Framework for Exercise Recovery, Overload, and Adaptation.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate acute and chronic exercise-induced changes in cell-free DNA (cfDNA) concentrations during a 7-day high-intensity interval training (HIIT) shock microcycle in trained endurance athletes. Thirty-five participants were randomly assigned to one of three groups: a HIIT-only group (HSM), a HIIT plus low-intensity training group (HSM + LIT), and a control group maintaining regular training. The intervention included 10 HIIT sessions (5 × 4 min at 90-95% maximum heart rate) over 7 days, with HSM + LIT completing an additional 30 min of low-intensity training after each session. Physiological exercise testing (PET) was conducted at baseline, 3-, 7-, and 14-days post-intervention. On days 2 and 7 during the intervention, HIIT sessions were supervised in both morning and afternoon, and venous blood samples were collected at rest, immediately post-exercise, and 30 min post-exercise to measure cfDNA for 90 and 222 bp fragments. Correlations between cfDNA and physiological exercise variables such as peak power output (PPO), running velocity at lactate threshold (LT), and VO₂
resultscfDNA
conclusionscfDNA is a reliable marker for detecting acute exercise-induced stress. However, the potential of cfDNA for detecting chronic adaptations in short-term, high-intensity interval training settings, such as a HIIT shock cycle, appears limited thus far. Trial registration clinicaltrials.gov, NCT05067426. Registered 05 October 2021-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05067426 .
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Registered trials
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