ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Clinical significance of non-invasive in vitro drug sensitivity profiling using pancreatic cancer organoids derived from saline flushes collected during routine EUS-FNA.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pancreatic organoids and organoid-on-a-chip platforms: from disease modeling to precision therapy.Journal of translational medicine · 2026Review
- Recent advances and expanding applications of organoid models in unveiling drug ADME profiles.Journal of pharmaceutical analysis · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the in vitro drug sensitivity of patient-derived cancer organoids (PDCOs) established from residual samples from saline flushes (RSSF) collected during routine endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in patients with pancreatic cancer.
methodsOrganoids were cultured under mutation-selective conditions. IC
resultsPDCOs showed variable responses to the drugs. Exploratory quantitative analysis using ordinal sensitivity scoring and ROC curves (Area under the curve [AUC] up to 0.917) indicated that lower in vitro IC₅₀ scores tended to associate with clinical responders (PR/uPR) compared with non-responders (progressive or stable disease [PD/SD]).
conclusionsThis study demonstrated the feasibility and potential usefulness of in vitro drug sensitivity profiling of pancreatic cancer using RSSF-derived PDCOs. These findings represent the first step toward clinical application, and further validation in larger cohorts is warranted.
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