Evidence map›Paper›PMID 41269559›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

In Vitro Lymphoid Differentiation of Human Hematopoietic Progenitor Cells from Co-cultures in Hypoxia.

Françoise Pflumio, Rima Haddad

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Françoise PflumioUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ, Fontenay-aux-Roses, France.
Rima HaddadUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ, Fontenay-aux-Roses, France. rima.haddad@universite-paris-saclay.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the identity of cells from which lymphoid differentiation occurs can be addressed using specific cell assays. Ex vivo conditions have been established based on co-culture systems between human hematopoietic stem/progenitor cells or early lymphoid progenitors and stromal cells. These systems provide a functional approach to carefully assess cell potential at both qualitative and quantitative levels. This chapter describes a two-step co-culture system for isolated hematopoietic stem/progenitor cells, using a murine bone marrow stromal cell line (MS-5), a hypoxic environment (3.5% O

Indexed as

Cell DifferentiationHematopoietic Stem CellsLymphocytesAnimalsCell HypoxiaCell LineCoculture TechniquesHumansMesenchymal Stem CellsMiceCo-culturesHuman CD34+ hemato-lymphoid progenitorsHypoxiaIn vitro lymphoid differentiationLimiting dilution assaysMS-5 stromal cellsUmbilical cord blood

Identifiers

PMID41269559

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.