Evidence map›Paper›PMID 41269570›Full record

ArticleMolecular diversity2026

Nitroquinolones and nitroquinolines: syntheses and antitrypanosomal activity.

Phelelisiwe S Dube, Karol R Francisco, Lesetja J Legoabe, Yujie Uli Sun, Yashpreet Kaur, Tina P Nguyen, Conor R Caffrey, Richard M Beteck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Phelelisiwe S DubeCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Karol R FranciscoCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9255 Pharmacy Lane, MC0657, La Jolla, CA, 92093, USA.
Lesetja J LegoabeCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Yujie Uli SunCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9255 Pharmacy Lane, MC0657, La Jolla, CA, 92093, USA.
Yashpreet KaurCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9255 Pharmacy Lane, MC0657, La Jolla, CA, 92093, USA.
Tina P NguyenCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9255 Pharmacy Lane, MC0657, La Jolla, CA, 92093, USA.
Conor R CaffreyCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9255 Pharmacy Lane, MC0657, La Jolla, CA, 92093, USA.
Richard M BeteckCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa. Richard.Beteck@nwu.ac.za.

Funding

RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
The catalytic core of the proteasome as a drug target to treat Human African TrypanosomiasisR21AI171824 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAFFREY, CONOR, O'DONOGHUE, ANTHONY JOHN · 2022 to 2023
$435k
NIAID NIH HHS R21 AI171824NIAID NIH HHS T32 AI007036
6 · The paper itself

Abstract

Nitroaromatic small molecules are established anti-infectives, including against trypanosomal diseases. Inspired by our previously identified suicide inhibitors of Mycobacterium tuberculosis (Mtb) decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1), we report the synthesis and in vitro antitrypanosomal activity of six novel nitroquinoline derivatives (4a-4f), as well as the antitrypanosomal activity of 13 previously described nitroquinolone anti-Mtb compounds, 8a-8 m. Two compounds exhibited sub-micromolar activity (EC

Indexed as

NitroquinolinesQuinolonesTrypanocidal AgentsTrypanosoma brucei bruceiMycobacterium tuberculosisStructure-Activity RelationshipNitroquinolinesQuinolonesTrypanocidal AgentsAfrican trypanosomiasisDprE1NitroaromaticsNitro-reductaseQuinolone

Identifiers

PMID41269570
PMCPMC13135320

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.