Recent advances in adamantane-linked heterocycles: synthesis and biological activity.

Last decade grabbed tremendous scientific attention towards the novel synthetic strategies for the synthesis and derivatization of adamantane core. Adamantane, owing to its unique chemical structure and high biological activity, has always been a subject of perpetual interest for medicinal chemists. The current review deals with the elucidation of the traditional and conventional methods as well as the application of novel methodologies for synthesizing the adamantane derivatives incorporating THREE, FOUR, FIVE, and SIX heterocyclic nuclei. Consequently, medicinal chemists have focused their efforts on compounds containing adamantane-based heterocycles to identify new therapeutic agents for various biological activities. For novelty, by screening the previous literature survey, we found no previously reported brief survey on the chemical modification of adamantane, especially the adamantane-based heterocyclic nuclei. In addition, the review attempts to inform researchers of how adamantane connected with different classified heterocyclic compounds, which incorporate either nitrogen, oxygen, and sulfur atoms, or combined two or all hetero atoms, as well as their engagement in diverse biological activities. Finally, we envision that the current review will successfully engage researchers in discovering novel, promising, simple materials for developing new various biological activities and drugs.