Evidence map›Paper›PMID 41269663›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Adipose tissue releases nucleosides.

Jing Zhang, Thuc Le, Veronica Ruiz-Torres, Michael Cohen, Vladislava Paharkova, Evan Abt, Hiba S Alnajjar, Jia Tan, Khalid Rashid, Anthony E Jones and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jing ZhangDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0000-0003-1958-8169
Thuc LeDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Veronica Ruiz-TorresDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Michael CohenDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Vladislava PaharkovaDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0009-0001-1509-7170
Evan AbtDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Hiba S AlnajjarDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Jia TanDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Khalid RashidDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Anthony E JonesDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Andréa B BallDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Ajit S DivakaruniDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0000-0002-2528-9651
Rebecca L PaszkiewiczDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Praveen BandaruCalifornia NanoSystems Institute, UCLA, Los Angeles, California, United States.
Julia J MackDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0000-0002-9239-8436
Julianne W AshbyDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.
Jiyoon KimDepartment of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, California, United States.
Gang LiDepartment of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, California, United States.
Caius G RaduDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0000-0002-9338-5397
Steven D MittelmanDivision of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine, UCLA, Los Angeles, California, United States.ORCID 0000-0003-2867-1298

Funding

Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancerR01CA260678 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, RADU, CAIUS GABRIEL · 2021 to 2025
$3.0M
Understanding How Metabolic Cofactors Control Cell Function and FateR35GM138003 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Ajit Divakaruni · 2020 to 2026
$2.8M
Adipocytes are Important Players in the Acute Lymphoblastic Leukemia MicroenvironmentR01CA201444 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITTELMAN, STEVEN DAVID · 2016 to 2020
$1.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS)NCI NIH HHS R01 CA201444NCI NIH HHS R01 CA260678NIGMS NIH HHS R35 GM138003NIH/NCI R01CA201444NIH/NCI R01CA260678UC | UCLA | Jonsson Comprehensive Cancer Center, University of California, Los Angeles (JCCC) n/a
6 · The paper itself

Abstract

It remains unclear how excess adipose tissue in obesity leads to inflammation, insulin resistance, and other comorbidities. Extracellular nucleosides can induce inflammation through the activation of immune cell toll-like and purinergic receptors. The present study quantified nucleoside release from adipocytes and adipose tissue. Cultured mouse adipocytes released many nucleosides used in RNA/DNA. Adipose tissue from obese mice released more nucleosides than that from control nonobese mice ex vivo and had higher interstitial fluid concentrations in vivo. Consistent with the mouse study, human adipose tissue also showed significant release of adenosine/deoxyadenosine, guanosine/deoxyguanosine, and uridine ex vivo. Adipocytes release nucleosides in part through the equilibrative nucleoside transporter 1, though other pathways also appear to contribute to extracellular nucleoside concentrations. Extracellular nucleosides induce adipose tissue expression of inflammatory cytokines

Indexed as

AdipocytesAdipose TissueNucleosidesObesityAnimalsCytokinesEquilibrative Nucleoside Transporter 1FemaleHumansInflammationMaleMiceMice, Inbred C57BLMice, ObeseCytokinesEquilibrative Nucleoside Transporter 1Nucleosidesadiposeinflammationmicroenvironmentnucleosidesobesity

Identifiers

PMID41269663
PMCPMC12742186

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.