Evidence map›Paper›PMID 41269698›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes.

Owen R Vaughan, Andrew Goodspeed, Carmen C Sucharov, Theresa L Powell, Thomas Jansson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Owen R VaughanDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-7537-3264
Andrew GoodspeedUniversity of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Carmen C SucharovDepartment of Cardiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0003-0349-1776
Theresa L PowellDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Thomas JanssonDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-8123-9480

Funding

University of Colorado Cancer Center Support GrantP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · 1988 to 2025
$33.7M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
CU | Center for Women's Health Research, University of Colorado (CWHR, UC)HHS | National Institutes of Health (NIH) P30CA046934HHS | National Institutes of Health (NIH) P30DK048520HHS | National Institutes of Health (NIH) R01HD065007NCI NIH HHS P30 CA046934NICHD NIH HHS R01 HD065007NIDDK NIH HHS P30 DK048520UKRI | Medical Research Council (MRC) MR/W028301/1
6 · The paper itself

Abstract

Obesity in pregnant women increases offspring cardiovascular risk and causes fetal cardiac dysfunction. The underpinning mechanisms remain unclear. We hypothesized that circulating factors in serum from fetuses of women with obesity induce pathological cardiomyocyte hypertrophy. Pregnant women with obesity or healthy weight were recruited at term and provided umbilical cord serum and placentas, which were used for isolation of primary trophoblast cells. Primary cardiomyocytes were isolated from neonatal rats. Compared with cord serum from healthy weight women, cord serum from women with obesity upregulated cardiomyocyte mRNA expression of atrial natriuretic factor (

Indexed as

CardiomegalyFetal BloodMyocytes, CardiacObesityPregnancy in ObesityAdultAnimalsAnimals, NewbornAtrial Natriuretic FactorCardiac MyosinsCase-Control StudiesCells, CulturedFemaleHumansMicroRNAsMyosin Heavy ChainsAtrial Natriuretic FactorCardiac MyosinsMicroRNAsMYH7 protein, humanMYH7 protein, ratMyosin Heavy ChainsNatriuretic Peptide, BrainVentricular Myosinscardiomyopathy, hypertrophicdiabetes, gestationalexosomesfetal organ maturitymetabolic syndrome

Identifiers

PMID41269698
PMCPMC12719755

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.