ArticlePloS one2025
Clinical characteristics and predictive models for hospitalized patients with COVID-19 combined with bacterial pneumonia.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundThis study aimed to analyze the clinical characteristics of hospitalized patients with COVID-19 combined with bacterial pneumonia and establish a predictive model to assist clinicians in the differential diagnosis and evaluation of the effectiveness of antibiotic treatment.
methodsIn this retrospective study, we collected clinical, biochemical, imaging, and microbiological data from hospitalized patients with COVID-19 admitted to our hospital between December 1, 2022, and February 7, 2023. Univariate and multivariate analyses revealed independent risk factors for bacterial pneumonia in COVID-19 patients. Model performance was assessed via the area under the curve (AUC).
resultsA total of 5358 COVID-19 patients were screened, and data from 1794 patients were ultimately included; 1386 patients had concomitant bacterial pneumonia (77.3%), whereas 408 patients served as controls (22.7%). Among COVID-19 patients, those with concomitant bacterial pneumonia had lower levels of albumin, hemoglobin, and lymphocyte ratio, along with higher levels of procalcitonin, globulin, glucose, urea, white blood cell count, and neutrophil ratio, than patients without bacterial pneumonia. Sputum cultures identified Acinetobacter baumanii, Klebsiella pneumoniae, and Pseudomonas aeruginosa as the top three bacterial species. A predictive model for the early detection of concomitant bacterial pneumonia in COVID-19 patients was developed via multivariate regression analysis, with an AUC of 0.850 (p < 0.001).
conclusionThese findings provide valuable insights for clinicians in the early diagnosis of bacterial pneumonia in COVID-19 patients, which may facilitate timely intervention and treatment.
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