Evidence mapPaperPMID 41270210Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia-Reperfusion Injury.

Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lu WangDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Chao HouDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Shuo LiDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Lizhi YangDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Yiqun LinDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Sen WangDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xiaohua JiaKey Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Hui HuiKey Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Wen HeDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.ORCID https://orcid.org/0000-0002-8427-971X
Wei ZhangDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.ORCID https://orcid.org/0000-0002-9743-1063

Funding

National Natural Science Foundation of China 82271995National Natural Science Foundation of China 92259303
6 · The paper itself

Abstract

Even after successful revascularization in acute ischemic stroke, some patients still develop secondary neuronal damage and functional impairment, known as cerebral ischemia-reperfusion injury (CIRI). The complex pathophysiological cascade within CIRI limits the efficacy of current single-target therapies in clinical practice. To address this, this study innovatively constructs a multifunctional brain-targeted nanoplatform (RFP) designed to synergistically intervene in the multiple pathological pathways of CIRI. This platform co-delivers Pt-based MXene nanozymes (Pt-Ti

Indexed as

AntioxidantsBrain IschemiaFerroptosisNeuroprotective AgentsReperfusion InjuryAnimalsDisease Models, AnimalHumansMaleMiceNanoparticlesNitritesOxidative StressTransition ElementsAntioxidantsMXeneNeuroprotective AgentsNitritesTransition Elementscerebral ischemia‐reperfusion injuryinflammatory microenvironment remodelingMXene nanozymesneuronal ferroptosisoxidative stress

Identifiers

PMID41270210
PMCPMC12866792

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.