Evidence map›Paper›PMID 41270215›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.

Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shan ZhongDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Xueyu WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Qingsong LiBGI Research, Beijing, 102601, P. R. China.
Siqi WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Bin SunResearch Center for Pharmacoinformatics (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin, 150081, P. R. China.
Wenjun NiHeilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, 150081, P. R. China.
Gengyu ZhouDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Fan WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Xianwei XieDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Cheng JinHeilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, 150081, P. R. China.
Gang XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, 150081, P. R. China.
Peng ZhaoDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Xiang PengDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Feiyuan HanDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Xiangwen XiHeilongjiang Provincial Key Laboratory of Panvascular Disease, Harbin, 150081, P. R. China.
Yidan WangDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Juan XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, 150081, P. R. China.
Yue WangBGI Research, Beijing, 102601, P. R. China.
Xia GuDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Shuo LiDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.
Jian ZhangSchool of Pharmacy, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Shuijie LiCollege of Pharmacy, Harbin Medical University, Harbin, 150081, P. R. China.
Jinwei TianDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, P. R. China.ORCID https://orcid.org/0000-0002-2730-0033

Funding

Heilongjiang Provincial Natural Science Foundation PL2024H133Key Laboratory of Myocardial Ischemia, Ministry of Education KF202108key research projects of Ningxia Medical University XJKF230110National Natural Science Foundation of China 82273244National Natural Science Foundation of China 82370068National Natural Science Foundation of China 82370343National Natural Science Foundation of China 82525006National Natural Science Foundation of China U21A20391National Natural Science Foundation of China U23A20581Noncommunicable Chronic Diseases-National Science and Technology Major Project 2025ZD0547001
6 · The paper itself

Abstract

The residual risks of advanced atherosclerosis remain substantial despite current preventive strategies and pharmacotherapy. Circulating branched-chain amino acids are biomarkers of cardiovascular disease risk. However, the mechanism of leucine in atherosclerosis progression remains unclear. Leucine transporter-SLC7A5-mediated leucine intake that promotes advanced atherosclerosis in mice, increasing apoptotic macrophages and lipids accumulation within plaques. Multi-omics analyses showed that leucine deprivation enhanced macrophage mitochondrial function and increased plaque CD5L

Indexed as

AtherosclerosisLarge Neutral Amino Acid-Transporter 1LeucineMacrophagesMitochondriaAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLLarge Neutral Amino Acid-Transporter 1Leucineadvanced atherosclerosisleucinemacrophagesmitochondriaPGAM5SLC7A5

Identifiers

PMID41270215
PMCPMC12866778

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.